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• W2022487907 abstract "Abstract MicroRNAs (miRNAs) regulate gene expression by inhibiting translation or targeting messenger RNA (mRNA) for degradation in a posttranscriptional fashion. In this study, we show that ectopic expression of miR-34a-5p reduces the mRNA and protein levels of Krüppel-like factor 4 (KLF4). We also demonstrate that miR-34a targets the 3′-untranslated mRNA region of KLF4 and show that overexpression of miR-34a induces a significant level of apoptosis in BNL CL.2 cells exposed to doxorubicin or 10 Gy X-ray. Our data suggest that the effects of miR-34a on apoptosis occur due to the downregulation of KLF4." @default.
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• W2022487907 date "2014-01-01" @default.
• W2022487907 modified "2023-10-18" @default.
• W2022487907 title "MiR-34a regulates apoptosis in liver cells by targeting the KLF4 gene" @default.
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• W2022487907 doi "https://doi.org/10.2478/s11658-013-0115-y" @default.
• W2022487907 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6275989" @default.
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