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• W2022490202 abstract "The Chinese hamster cell line V79-4 and two ionising radiation-sensitive mutants irs1 and irs3, were used to assess the genotoxic effects of a clastogen (X-rays), an aneugen (podophyllotoxin) and an agent having both activities (etoposide), using the cytokinesis-block micronucleus assay combined with kinetochore labelling. All three agents induced micronuclei in a dose-dependent manner. Between 70 and 90% of the micronuclei induced by X-rays were kinetochore-negative and indicative of clastogenic activity, the relative frequencies of which were increased in the repair-deficient cell lines. In contrast, podophyllotoxin induced mainly kinetochore-positive micronuclei (up to 97%) and could be classified as an inducer of chromosome lagging and was essentially aneugenic in its activity. Micronuclei induced by etoposide were 61–84% kinetochore-negative and 26–39% kinetochore-positive, indicating both clastogenic and aneugenic activity. In the case of both etoposide and podophyllotoxin, there were no observed differences in the induction of micronuclei between the wild-type and repair-deficient cell lines. The data demonstrate the effectiveness of the cytokinesis-block micronucleus/kinetochore assay in determining the mechanisms of action of both chemicals and radiations upon chromosome structure and number and the potential influences of repair upon micronuclei induction." @default.
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• W2022490202 date "1997-08-01" @default.
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• W2022490202 title "Comparative induction of micronuclei in repair-deficient and -proficient Chinese hamster cell lines following clastogen or aneugen exposures" @default.
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• W2022490202 doi "https://doi.org/10.1016/s0165-1218(97)00053-0" @default.
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