FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022491750> ?p ?o ?g. }

• W2022491750 endingPage "1733" @default.
• W2022491750 startingPage "1726" @default.
• W2022491750 abstract "The mammalian brain contains neural stem cells (NSCs) that allow continued neurogenesis throughout the life of the animal. However, neurogenesis is known to decline during aging and, to the extent that neurogenesis is required for normal CNS function, this may contribute to neurodegenerative disease. Decreased neurogenesis could result from loss of NSCs or dysfunction at some later step, and distinguishing these possibilities is important for understanding the cause of the decline. However, because of the inability to distinguish NSCs from their rapidly dividing progeny in situ, it has not been possible to quantitatively assess the NSC populations in young and old animals. In this report we show that the G1 phase-specific expression of the replication factor Mcm2 is a useful marker for detecting slowly cycling putative NSCs in situ and confirm the identity of these cells using both cytosine beta-D-arabinofuranoside (Ara-C) treatment and a double nucleoside analog-labeling technique. The ability to distinguish NSCs from proliferative progenitors has allowed characterization of the expression of several markers including Nestin, Musashi, and GFAP in these different cell types. Furthermore, comparison of the NSC populations in the subventricular zones of young (2-4 months) and old (24-26 months) mice demonstrates an approximately twofold reduction in the older mice. A similar twofold reduction is also observed in the number of neurospheres recovered in culture from old relative to young animals. The reduction in the neural stem cell population documented here is sufficient to account for the reduced level of neurogenesis in old animals." @default.
• W2022491750 created "2016-06-24" @default.
• W2022491750 creator A5000002403 @default.
• W2022491750 creator A5029498369 @default.
• W2022491750 creator A5055273811 @default.
• W2022491750 creator A5088500348 @default.
• W2022491750 date "2004-02-18" @default.
• W2022491750 modified "2023-09-25" @default.
• W2022491750 title "Neural Stem Cell Detection, Characterization, and Age-Related Changes in the Subventricular Zone of Mice" @default.
• W2022491750 cites W1670625131 @default.
• W2022491750 cites W1780273906 @default.
• W2022491750 cites W1835059569 @default.
• W2022491750 cites W1859730138 @default.
• W2022491750 cites W1890013982 @default.
• W2022491750 cites W1967876791 @default.
• W2022491750 cites W1968506175 @default.
• W2022491750 cites W1968863900 @default.
• W2022491750 cites W1980499453 @default.
• W2022491750 cites W1985801522 @default.
• W2022491750 cites W1987035864 @default.
• W2022491750 cites W1989495647 @default.
• W2022491750 cites W1995094909 @default.
• W2022491750 cites W1996907803 @default.
• W2022491750 cites W2006740924 @default.
• W2022491750 cites W2009492491 @default.
• W2022491750 cites W2009947065 @default.
• W2022491750 cites W2010641214 @default.
• W2022491750 cites W2024667339 @default.
• W2022491750 cites W2030508161 @default.
• W2022491750 cites W2055561480 @default.
• W2022491750 cites W2058740317 @default.
• W2022491750 cites W2067856703 @default.
• W2022491750 cites W2078504009 @default.
• W2022491750 cites W2079356804 @default.
• W2022491750 cites W2079776787 @default.
• W2022491750 cites W2092397904 @default.
• W2022491750 cites W2097857054 @default.
• W2022491750 cites W2108567185 @default.
• W2022491750 cites W2112473132 @default.
• W2022491750 cites W2112549882 @default.
• W2022491750 cites W2136648118 @default.
• W2022491750 cites W2145430337 @default.
• W2022491750 cites W2154104720 @default.
• W2022491750 cites W2160280025 @default.
• W2022491750 cites W2161687882 @default.
• W2022491750 cites W2165867905 @default.
• W2022491750 doi "https://doi.org/10.1523/jneurosci.4608-03.2004" @default.
• W2022491750 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6730468" @default.
• W2022491750 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14973255" @default.
• W2022491750 hasPublicationYear "2004" @default.
• W2022491750 type Work @default.
• W2022491750 sameAs 2022491750 @default.
• W2022491750 citedByCount "482" @default.
• W2022491750 countsByYear W20224917502012 @default.
• W2022491750 countsByYear W20224917502013 @default.
• W2022491750 countsByYear W20224917502014 @default.
• W2022491750 countsByYear W20224917502015 @default.
• W2022491750 countsByYear W20224917502016 @default.
• W2022491750 countsByYear W20224917502017 @default.
• W2022491750 countsByYear W20224917502018 @default.
• W2022491750 countsByYear W20224917502019 @default.
• W2022491750 countsByYear W20224917502020 @default.
• W2022491750 countsByYear W20224917502021 @default.
• W2022491750 countsByYear W20224917502022 @default.
• W2022491750 countsByYear W20224917502023 @default.
• W2022491750 crossrefType "journal-article" @default.
• W2022491750 hasAuthorship W2022491750A5000002403 @default.
• W2022491750 hasAuthorship W2022491750A5029498369 @default.
• W2022491750 hasAuthorship W2022491750A5055273811 @default.
• W2022491750 hasAuthorship W2022491750A5088500348 @default.
• W2022491750 hasBestOaLocation W20224917501 @default.
• W2022491750 hasConcept C104317684 @default.
• W2022491750 hasConcept C136834591 @default.
• W2022491750 hasConcept C148738053 @default.
• W2022491750 hasConcept C162746124 @default.
• W2022491750 hasConcept C169760540 @default.
• W2022491750 hasConcept C201750760 @default.
• W2022491750 hasConcept C20875687 @default.
• W2022491750 hasConcept C2777542384 @default.
• W2022491750 hasConcept C2777738006 @default.
• W2022491750 hasConcept C28328180 @default.
• W2022491750 hasConcept C2908647359 @default.
• W2022491750 hasConcept C4746552 @default.
• W2022491750 hasConcept C54355233 @default.
• W2022491750 hasConcept C71924100 @default.
• W2022491750 hasConcept C86803240 @default.
• W2022491750 hasConcept C95444343 @default.
• W2022491750 hasConcept C99454951 @default.
• W2022491750 hasConceptScore W2022491750C104317684 @default.
• W2022491750 hasConceptScore W2022491750C136834591 @default.
• W2022491750 hasConceptScore W2022491750C148738053 @default.
• W2022491750 hasConceptScore W2022491750C162746124 @default.
• W2022491750 hasConceptScore W2022491750C169760540 @default.
• W2022491750 hasConceptScore W2022491750C201750760 @default.
• W2022491750 hasConceptScore W2022491750C20875687 @default.
• W2022491750 hasConceptScore W2022491750C2777542384 @default.
• W2022491750 hasConceptScore W2022491750C2777738006 @default.
• W2022491750 hasConceptScore W2022491750C28328180 @default.

• next