FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022505363> ?p ?o ?g. }

• W2022505363 endingPage "259" @default.
• W2022505363 startingPage "255" @default.
• W2022505363 abstract "Objectives. 1) To investigate ECG changes following co-proxamol (paracetamol 325 mg and dextropropoxyphene 32.5 mg) overdose in comparison to co-codamol (paracetamol and codeine) or co-dydramol (paracetamol and dihydrocodeine) in a prospective study. 2) To examine the relationship between estimated dextropropoxyphene dose and ECG changes in a larger patient population. Background. Co-proxamol is a common cause of drug-induced death and hospital admission in the United Kingdom. ECG changes following dextropropoxyphene have been reported in animals and man, including QRS prolongation. Methods. The prospective study was conducted on 15 patients and controls with overdose. A retrospective study of a cohort of 159 co-proxamol overdoses from a combined data set from Edinburgh and Newcastle, Australia was also conducted. The measured or estimated “four hour” plasma paracetamol level was used as a surrogate of the amount of dextropropoxyphene ingested. Results. In the prospective study co-proxamol overdose caused statistically significant QRS prolongation (mean [95% CI] 99.36 [96.19, 102.53] msec), compared to the other combination opioid-paracetamol products (82.84 [80.81, 84.88] msec) but no effect on PR or QTc. QRS duration increase was evident soon after exposure and remained prolonged and stable over the following 24 h. In the retrospective cohort study a dose dependency of effect on QRS was documented, although the correlation coefficient relating paracetamol level to effect was relatively weak (r = 0.338, Sig. [2-tailed] 0.003, n = 74). Conclusions. QRS is significantly prolonged in co-proxamol overdose, and this prolongation is dose dependent. These findings have clinical relevance to the management of patients with co-proxamol poisoning." @default.
• W2022505363 created "2016-06-24" @default.
• W2022505363 creator A5029961929 @default.
• W2022505363 creator A5045025227 @default.
• W2022505363 creator A5062014095 @default.
• W2022505363 creator A5082516447 @default.
• W2022505363 date "2005-01-01" @default.
• W2022505363 modified "2023-10-06" @default.
• W2022505363 title "ECG Abnormalities in Co-proxamol (Paracetamol/Dextropropoxyphene) Poisoning" @default.
• W2022505363 cites W1967367675 @default.
• W2022505363 cites W1975633728 @default.
• W2022505363 cites W1976657733 @default.
• W2022505363 cites W1993984060 @default.
• W2022505363 cites W2021582270 @default.
• W2022505363 cites W2021661949 @default.
• W2022505363 cites W2037020765 @default.
• W2022505363 cites W2039143933 @default.
• W2022505363 cites W2048811304 @default.
• W2022505363 cites W2067086068 @default.
• W2022505363 cites W2069169015 @default.
• W2022505363 cites W2069884282 @default.
• W2022505363 cites W2074614933 @default.
• W2022505363 cites W2080617181 @default.
• W2022505363 cites W2087828985 @default.
• W2022505363 cites W2090242997 @default.
• W2022505363 cites W2092519507 @default.
• W2022505363 cites W2115197590 @default.
• W2022505363 cites W2124145234 @default.
• W2022505363 cites W2135376586 @default.
• W2022505363 cites W2138065639 @default.
• W2022505363 cites W2396354190 @default.
• W2022505363 cites W34877288 @default.
• W2022505363 cites W355096169 @default.
• W2022505363 cites W4210912142 @default.
• W2022505363 cites W4242880851 @default.
• W2022505363 doi "https://doi.org/10.1081/clt-66069" @default.
• W2022505363 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16035201" @default.
• W2022505363 hasPublicationYear "2005" @default.
• W2022505363 type Work @default.
• W2022505363 sameAs 2022505363 @default.
• W2022505363 citedByCount "29" @default.
• W2022505363 countsByYear W20225053632012 @default.
• W2022505363 countsByYear W20225053632013 @default.
• W2022505363 countsByYear W20225053632014 @default.
• W2022505363 countsByYear W20225053632015 @default.
• W2022505363 countsByYear W20225053632017 @default.
• W2022505363 countsByYear W20225053632018 @default.
• W2022505363 countsByYear W20225053632019 @default.
• W2022505363 countsByYear W20225053632020 @default.
• W2022505363 countsByYear W20225053632021 @default.
• W2022505363 countsByYear W20225053632022 @default.
• W2022505363 crossrefType "journal-article" @default.
• W2022505363 hasAuthorship W2022505363A5029961929 @default.
• W2022505363 hasAuthorship W2022505363A5045025227 @default.
• W2022505363 hasAuthorship W2022505363A5062014095 @default.
• W2022505363 hasAuthorship W2022505363A5082516447 @default.
• W2022505363 hasConcept C111773187 @default.
• W2022505363 hasConcept C118441451 @default.
• W2022505363 hasConcept C126322002 @default.
• W2022505363 hasConcept C188816634 @default.
• W2022505363 hasConcept C194828623 @default.
• W2022505363 hasConcept C2776315796 @default.
• W2022505363 hasConcept C2777389121 @default.
• W2022505363 hasConcept C2777866328 @default.
• W2022505363 hasConcept C2780820201 @default.
• W2022505363 hasConcept C2908647359 @default.
• W2022505363 hasConcept C3017944768 @default.
• W2022505363 hasConcept C42219234 @default.
• W2022505363 hasConcept C508975757 @default.
• W2022505363 hasConcept C71924100 @default.
• W2022505363 hasConcept C99454951 @default.
• W2022505363 hasConceptScore W2022505363C111773187 @default.
• W2022505363 hasConceptScore W2022505363C118441451 @default.
• W2022505363 hasConceptScore W2022505363C126322002 @default.
• W2022505363 hasConceptScore W2022505363C188816634 @default.
• W2022505363 hasConceptScore W2022505363C194828623 @default.
• W2022505363 hasConceptScore W2022505363C2776315796 @default.
• W2022505363 hasConceptScore W2022505363C2777389121 @default.
• W2022505363 hasConceptScore W2022505363C2777866328 @default.
• W2022505363 hasConceptScore W2022505363C2780820201 @default.
• W2022505363 hasConceptScore W2022505363C2908647359 @default.
• W2022505363 hasConceptScore W2022505363C3017944768 @default.
• W2022505363 hasConceptScore W2022505363C42219234 @default.
• W2022505363 hasConceptScore W2022505363C508975757 @default.
• W2022505363 hasConceptScore W2022505363C71924100 @default.
• W2022505363 hasConceptScore W2022505363C99454951 @default.
• W2022505363 hasIssue "4" @default.
• W2022505363 hasLocation W20225053631 @default.
• W2022505363 hasLocation W20225053632 @default.
• W2022505363 hasOpenAccess W2022505363 @default.
• W2022505363 hasPrimaryLocation W20225053631 @default.
• W2022505363 hasRelatedWork W1967891338 @default.
• W2022505363 hasRelatedWork W2022505363 @default.
• W2022505363 hasRelatedWork W2110511993 @default.
• W2022505363 hasRelatedWork W2144572520 @default.
• W2022505363 hasRelatedWork W2409960961 @default.
• W2022505363 hasRelatedWork W2412655175 @default.
• W2022505363 hasRelatedWork W2417800539 @default.

• next