FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022506684> ?p ?o ?g. }

• W2022506684 endingPage "320" @default.
• W2022506684 startingPage "312" @default.
• W2022506684 abstract "Methylphenidate (MPD) is widely prescribed for the treatment of attention deficit disorders in children and has generally been thought to be free of significant side effects when administered at recommended therapeutic doses. However, recent behavioral research with laboratory rodents has indicated that, like other psychostimulants with which it shares neurotransmitter-modulating properties, chronically administered MPD can bring about lasting and potentially detrimental alterations in brain function. Some of these may involve changes in the neuromodulatory input from noradrenergic and dopaminergic systems that project to the prefrontal cortex and hippocampus, regions with significant roles in several cognitive functions, including those critical to memory formation. To investigate the possibility of cognitive impairment, the effects of a regimen of chronic MPD on the performance of an object recognition task known to rely on the integrity of systems involved in rodent memory was assessed. The drug, at doses of 2, 3 or 5mg/kg, was delivered twice daily to periadolescent rats via an oral administration technique on either 11 or 21 treatment days. Subsequent to this period, the animals were subjected to an object recognition test at 14, 28, and 42 days after their last MPD treatment. In each of these tests, exploration time for two objects, one novel and one previously encountered (3h earlier), was assessed. Longer exploration of the novel object was considered evidence of retained memory for the familiar object. It was found that rats exposed to 3 or 5mg/kg (b.i.d.) on 21 occasions exhibited no significant preference for exploration of the novel object at any of the three post-treatment intervals. This finding was interpreted as evidence of a persisting MPD-induced impairment of recognition memory in these animals." @default.
• W2022506684 created "2016-06-24" @default.
• W2022506684 creator A5045472983 @default.
• W2022506684 creator A5064760517 @default.
• W2022506684 date "2007-10-01" @default.
• W2022506684 modified "2023-09-26" @default.
• W2022506684 title "Chronic oral methylphenidate administration to periadolescent rats yields prolonged impairment of memory for objects" @default.
• W2022506684 cites W1900959016 @default.
• W2022506684 cites W1965719218 @default.
• W2022506684 cites W1969454703 @default.
• W2022506684 cites W1974998836 @default.
• W2022506684 cites W1978012897 @default.
• W2022506684 cites W1980494785 @default.
• W2022506684 cites W1983051670 @default.
• W2022506684 cites W1986886791 @default.
• W2022506684 cites W1991044871 @default.
• W2022506684 cites W2001997032 @default.
• W2022506684 cites W2003128711 @default.
• W2022506684 cites W2008123860 @default.
• W2022506684 cites W2009436984 @default.
• W2022506684 cites W2010792949 @default.
• W2022506684 cites W2014371439 @default.
• W2022506684 cites W2018297368 @default.
• W2022506684 cites W2018654578 @default.
• W2022506684 cites W2018986141 @default.
• W2022506684 cites W2019924561 @default.
• W2022506684 cites W2021733070 @default.
• W2022506684 cites W2022887418 @default.
• W2022506684 cites W2030483725 @default.
• W2022506684 cites W2032517670 @default.
• W2022506684 cites W2037164190 @default.
• W2022506684 cites W2037625488 @default.
• W2022506684 cites W2044400361 @default.
• W2022506684 cites W2051315778 @default.
• W2022506684 cites W2051459893 @default.
• W2022506684 cites W2055912143 @default.
• W2022506684 cites W2065909153 @default.
• W2022506684 cites W2072441360 @default.
• W2022506684 cites W2074051583 @default.
• W2022506684 cites W2075675624 @default.
• W2022506684 cites W2090310294 @default.
• W2022506684 cites W2095751605 @default.
• W2022506684 cites W2116795024 @default.
• W2022506684 cites W2140513029 @default.
• W2022506684 cites W2141419779 @default.
• W2022506684 cites W2148399921 @default.
• W2022506684 cites W2150255019 @default.
• W2022506684 cites W2159875740 @default.
• W2022506684 cites W4213265599 @default.
• W2022506684 cites W9766445 @default.
• W2022506684 doi "https://doi.org/10.1016/j.nlm.2007.04.010" @default.
• W2022506684 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17544718" @default.
• W2022506684 hasPublicationYear "2007" @default.
• W2022506684 type Work @default.
• W2022506684 sameAs 2022506684 @default.
• W2022506684 citedByCount "48" @default.
• W2022506684 countsByYear W20225066842012 @default.
• W2022506684 countsByYear W20225066842013 @default.
• W2022506684 countsByYear W20225066842014 @default.
• W2022506684 countsByYear W20225066842015 @default.
• W2022506684 countsByYear W20225066842016 @default.
• W2022506684 countsByYear W20225066842017 @default.
• W2022506684 countsByYear W20225066842018 @default.
• W2022506684 countsByYear W20225066842019 @default.
• W2022506684 countsByYear W20225066842020 @default.
• W2022506684 countsByYear W20225066842021 @default.
• W2022506684 countsByYear W20225066842022 @default.
• W2022506684 crossrefType "journal-article" @default.
• W2022506684 hasAuthorship W2022506684A5045472983 @default.
• W2022506684 hasAuthorship W2022506684A5064760517 @default.
• W2022506684 hasConcept C118552586 @default.
• W2022506684 hasConcept C137183658 @default.
• W2022506684 hasConcept C15744967 @default.
• W2022506684 hasConcept C169760540 @default.
• W2022506684 hasConcept C169900460 @default.
• W2022506684 hasConcept C2777112843 @default.
• W2022506684 hasConcept C2780783007 @default.
• W2022506684 hasConcept C2781161787 @default.
• W2022506684 hasConcept C2781195155 @default.
• W2022506684 hasConcept C2909666625 @default.
• W2022506684 hasConcept C513476851 @default.
• W2022506684 hasConceptScore W2022506684C118552586 @default.
• W2022506684 hasConceptScore W2022506684C137183658 @default.
• W2022506684 hasConceptScore W2022506684C15744967 @default.
• W2022506684 hasConceptScore W2022506684C169760540 @default.
• W2022506684 hasConceptScore W2022506684C169900460 @default.
• W2022506684 hasConceptScore W2022506684C2777112843 @default.
• W2022506684 hasConceptScore W2022506684C2780783007 @default.
• W2022506684 hasConceptScore W2022506684C2781161787 @default.
• W2022506684 hasConceptScore W2022506684C2781195155 @default.
• W2022506684 hasConceptScore W2022506684C2909666625 @default.
• W2022506684 hasConceptScore W2022506684C513476851 @default.
• W2022506684 hasIssue "3" @default.
• W2022506684 hasLocation W20225066841 @default.
• W2022506684 hasLocation W20225066842 @default.
• W2022506684 hasOpenAccess W2022506684 @default.
• W2022506684 hasPrimaryLocation W20225066841 @default.
• W2022506684 hasRelatedWork W1952063656 @default.

• next