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- W2022507595 abstract "The treatment of acute hematogenous bone and joint infections of children - osteomyelitis (OM), septic arthritis (SA) and OM-SA combination (OM+SA) - has simplified over the past years. The old approach included months-long antibiotic treatment, started intravenously for at least a week, followed by oral completion of the course. Recent prospective randomized trials show that most cases heal with a total course of 3 weeks (OM, OM+SA) or 2 weeks (SA) of an appropriate antibiotic, provided the clinical response is good and C-reactive protein level has normalized. If the prevalence of methicillin-resistant Staphylococcus aureus and Kingella kingae is low, clindamycin and a first-generation cephalosporin are safe, inexpensive and effective alternatives. They should be administered in large doses and four times a day. Clindamycin, vancomycin and expensive linezolid are options against methicillin-resistant Staphylococcus aureus. Extensive surgery beyond a diagnostic sample by aspiration is rarely needed in uncomplicated cases." @default.
- W2022507595 created "2016-06-24" @default.
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- W2022507595 date "2011-12-01" @default.
- W2022507595 modified "2023-09-27" @default.
- W2022507595 title "Simplifying the treatment of acute bacterial bone and joint infections in children" @default.
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- W2022507595 doi "https://doi.org/10.1586/eri.11.140" @default.
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