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• W2022508086 abstract "The breast undergoes dramatic changes in size, shape, and function in association with growth, reproduction, and post-menopausal regression. Those changes impact women's lifetime breast cancer risk. An early first full-term pregnancy exerts a protective effect, emphasizing the need for understanding the role of reproductive influences on breast development and on cancer initiation and progression, and providing a paradigm for developing preventive strategies based on physiological principles. Even though the cause of breast cancer and the ultimate mechanisms through which an early pregnancy protects from cancer development remain largely unknown, a likely explanation for this protection has been provided by experimental in vivo and in vitro models. These studies have led to the conclusions that cancer initiation requires the interaction of a carcinogen with an undifferentiated and highly proliferating mammary epithelium, whereas differentiation of the mammary gland inhibits carcinogenic initiation. The process of mammary gland differentiation is the result of complex interactions of ovarian, pituitary, and placental hormones, which in turn induce inhibition of cell proliferation, downregulation of estrogen and progesterone receptors, activation of specific genes, such as inhibin, mammary derived growth factor inhibitor and a serpin-like gene, and expression of extracellular matrix proteins in the normal breast. Cell immortalization and transformation are associated with the expression of ferritin H and S100P protein, which serve as markers of cancer initiation. Comparative studies of normal and neoplastic breast development have unraveled similarities with experimental models that validate the extrapolation of findings for testing hypotheses on the initiation and progression of breast cancer." @default.
• W2022508086 created "2016-06-24" @default.
• W2022508086 creator A5039848713 @default.
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• W2022508086 creator A5054880138 @default.
• W2022508086 date "2001-01-01" @default.
• W2022508086 modified "2023-09-24" @default.
• W2022508086 title "Cancer risk related to mammary gland structure and development" @default.
• W2022508086 cites W1495275626 @default.
• W2022508086 cites W1534686037 @default.
• W2022508086 cites W1566315211 @default.
• W2022508086 cites W1594629478 @default.
• W2022508086 cites W1660660796 @default.
• W2022508086 cites W1904731887 @default.
• W2022508086 cites W1965694677 @default.
• W2022508086 cites W1965972037 @default.
• W2022508086 cites W1966823049 @default.
• W2022508086 cites W1969626435 @default.
• W2022508086 cites W1969928750 @default.
• W2022508086 cites W1972164300 @default.
• W2022508086 cites W1973487449 @default.
• W2022508086 cites W1977032555 @default.
• W2022508086 cites W1978368163 @default.
• W2022508086 cites W1980421314 @default.
• W2022508086 cites W1984649171 @default.
• W2022508086 cites W1986642570 @default.
• W2022508086 cites W1988297300 @default.
• W2022508086 cites W1988933903 @default.
• W2022508086 cites W1989837580 @default.
• W2022508086 cites W1991476232 @default.
• W2022508086 cites W1992666480 @default.
• W2022508086 cites W1998507980 @default.
• W2022508086 cites W2000001372 @default.
• W2022508086 cites W2000378895 @default.
• W2022508086 cites W2000971601 @default.
• W2022508086 cites W2002263141 @default.
• W2022508086 cites W2004699574 @default.
• W2022508086 cites W2006008730 @default.
• W2022508086 cites W2010240655 @default.
• W2022508086 cites W2010344294 @default.
• W2022508086 cites W2010920141 @default.
• W2022508086 cites W2011612270 @default.
• W2022508086 cites W2011888550 @default.
• W2022508086 cites W2015331626 @default.
• W2022508086 cites W2015938432 @default.
• W2022508086 cites W2019334296 @default.
• W2022508086 cites W2020209752 @default.
• W2022508086 cites W2023930045 @default.
• W2022508086 cites W2030286885 @default.
• W2022508086 cites W2031183930 @default.
• W2022508086 cites W2031230241 @default.
• W2022508086 cites W2033332053 @default.
• W2022508086 cites W2035070777 @default.
• W2022508086 cites W2036486872 @default.
• W2022508086 cites W2036765877 @default.
• W2022508086 cites W2037131591 @default.
• W2022508086 cites W2039412245 @default.
• W2022508086 cites W2044358078 @default.
• W2022508086 cites W2045752953 @default.
• W2022508086 cites W2047741256 @default.
• W2022508086 cites W2051582871 @default.
• W2022508086 cites W2051650083 @default.
• W2022508086 cites W2066743380 @default.
• W2022508086 cites W2068313312 @default.
• W2022508086 cites W2071934246 @default.
• W2022508086 cites W2072364202 @default.
• W2022508086 cites W2072942230 @default.
• W2022508086 cites W2075788654 @default.
• W2022508086 cites W2075924795 @default.
• W2022508086 cites W2076264685 @default.
• W2022508086 cites W2080979280 @default.
• W2022508086 cites W2087238390 @default.
• W2022508086 cites W2091287612 @default.
• W2022508086 cites W2096309768 @default.
• W2022508086 cites W2099446928 @default.
• W2022508086 cites W2101336097 @default.
• W2022508086 cites W2115339053 @default.
• W2022508086 cites W2115525961 @default.
• W2022508086 cites W2132632471 @default.
• W2022508086 cites W2134350919 @default.
• W2022508086 cites W2137161531 @default.
• W2022508086 cites W2140409748 @default.
• W2022508086 cites W2153839710 @default.
• W2022508086 cites W2158593262 @default.
• W2022508086 cites W2164692123 @default.
• W2022508086 cites W2169455407 @default.
• W2022508086 cites W2169509620 @default.
• W2022508086 cites W2254634882 @default.
• W2022508086 cites W2336959581 @default.
• W2022508086 cites W2406010029 @default.
• W2022508086 cites W2414220764 @default.
• W2022508086 cites W2484048815 @default.
• W2022508086 cites W2500603961 @default.
• W2022508086 cites W2506607 @default.
• W2022508086 cites W87767558 @default.
• W2022508086 doi "https://doi.org/10.1002/1097-0029(20010115)52:2<204::aid-jemt1006>3.0.co;2-f" @default.
• W2022508086 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11169868" @default.

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