FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022508149> ?p ?o ?g. }

• W2022508149 endingPage "7314" @default.
• W2022508149 startingPage "7302" @default.
• W2022508149 abstract "One of the characteristics of animals in hibernation is reduced behavioral activity. The Caenorhabditis elegans dauer state is a hibernation-like state of diapause that displays a dramatic reduction in spontaneous locomotion. A similar dauer-like quiescent state is produced in adults by relatively strong mutations in the insulin/IGF-1 receptor homolog daf-2 . In this study, we show that mutations affecting the neurotransmitter dopamine, which regulates voluntary movement in many organisms, can stimulate movement in dauers and dauer-like quiescent adults. Surprisingly, the movement of quiescent animals is stimulated by conditions that reduce dopamine signaling and also by conditions predicted to increase dopamine signaling. Reducing dopamine signaling is likely to stimulate movement by activating a foraging response also seen in nondauers after withdrawal of food. In contrast, the stimulation of movement by increased dopamine is much more pronounced in quiescent daf-2( − ) dauer and dauer-like adult animals than in nondauaer animals. This altered response to dopamine is primarily attributable to activity of the FOXO (forkhead box O) transcription factor DAF-16 in neurons. We suggest that dauers and dauer-like quiescent adults may have underlying changes in the dopamine system that enable them to respond differently to environmental stimulation." @default.
• W2022508149 created "2016-06-24" @default.
• W2022508149 creator A5053475144 @default.
• W2022508149 creator A5062218591 @default.
• W2022508149 date "2009-06-03" @default.
• W2022508149 modified "2023-10-14" @default.
• W2022508149 title "Stimulation of Movement in a Quiescent, Hibernation-Like Form of<i>Caenorhabditis elegans</i>by Dopamine Signaling" @default.
• W2022508149 cites W1486595217 @default.
• W2022508149 cites W1500923019 @default.
• W2022508149 cites W1581412826 @default.
• W2022508149 cites W1631908837 @default.
• W2022508149 cites W1849896091 @default.
• W2022508149 cites W1924308766 @default.
• W2022508149 cites W1964817556 @default.
• W2022508149 cites W1966145280 @default.
• W2022508149 cites W1973175580 @default.
• W2022508149 cites W1991080848 @default.
• W2022508149 cites W1998470289 @default.
• W2022508149 cites W2001920462 @default.
• W2022508149 cites W2003599098 @default.
• W2022508149 cites W2004117621 @default.
• W2022508149 cites W2004570705 @default.
• W2022508149 cites W2011664379 @default.
• W2022508149 cites W2014793858 @default.
• W2022508149 cites W2023018514 @default.
• W2022508149 cites W2025562786 @default.
• W2022508149 cites W2026075326 @default.
• W2022508149 cites W2030418096 @default.
• W2022508149 cites W2042330843 @default.
• W2022508149 cites W2043829280 @default.
• W2022508149 cites W2052722944 @default.
• W2022508149 cites W2062629127 @default.
• W2022508149 cites W2066660409 @default.
• W2022508149 cites W2069049686 @default.
• W2022508149 cites W2081267709 @default.
• W2022508149 cites W2088019468 @default.
• W2022508149 cites W2091613063 @default.
• W2022508149 cites W2092500788 @default.
• W2022508149 cites W2096267165 @default.
• W2022508149 cites W2102791000 @default.
• W2022508149 cites W2106937415 @default.
• W2022508149 cites W2107638414 @default.
• W2022508149 cites W2108024591 @default.
• W2022508149 cites W2112200758 @default.
• W2022508149 cites W2133782035 @default.
• W2022508149 cites W2142305917 @default.
• W2022508149 cites W2144498949 @default.
• W2022508149 cites W2145766592 @default.
• W2022508149 cites W2150485807 @default.
• W2022508149 cites W2152430821 @default.
• W2022508149 cites W2159565935 @default.
• W2022508149 cites W2159779491 @default.
• W2022508149 cites W2161758212 @default.
• W2022508149 cites W2162571565 @default.
• W2022508149 cites W2169126888 @default.
• W2022508149 cites W4238773213 @default.
• W2022508149 cites W4297832928 @default.
• W2022508149 doi "https://doi.org/10.1523/jneurosci.3429-08.2009" @default.
• W2022508149 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2919683" @default.
• W2022508149 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19494152" @default.
• W2022508149 hasPublicationYear "2009" @default.
• W2022508149 type Work @default.
• W2022508149 sameAs 2022508149 @default.
• W2022508149 citedByCount "50" @default.
• W2022508149 countsByYear W20225081492012 @default.
• W2022508149 countsByYear W20225081492013 @default.
• W2022508149 countsByYear W20225081492014 @default.
• W2022508149 countsByYear W20225081492015 @default.
• W2022508149 countsByYear W20225081492016 @default.
• W2022508149 countsByYear W20225081492017 @default.
• W2022508149 countsByYear W20225081492018 @default.
• W2022508149 countsByYear W20225081492019 @default.
• W2022508149 countsByYear W20225081492020 @default.
• W2022508149 countsByYear W20225081492021 @default.
• W2022508149 countsByYear W20225081492022 @default.
• W2022508149 countsByYear W20225081492023 @default.
• W2022508149 crossrefType "journal-article" @default.
• W2022508149 hasAuthorship W2022508149A5053475144 @default.
• W2022508149 hasAuthorship W2022508149A5062218591 @default.
• W2022508149 hasBestOaLocation W20225081491 @default.
• W2022508149 hasConcept C104317684 @default.
• W2022508149 hasConcept C11413529 @default.
• W2022508149 hasConcept C119865680 @default.
• W2022508149 hasConcept C169760540 @default.
• W2022508149 hasConcept C24998067 @default.
• W2022508149 hasConcept C2776219046 @default.
• W2022508149 hasConcept C2778944004 @default.
• W2022508149 hasConcept C41008148 @default.
• W2022508149 hasConcept C48103436 @default.
• W2022508149 hasConcept C513476851 @default.
• W2022508149 hasConcept C529278444 @default.
• W2022508149 hasConcept C54355233 @default.
• W2022508149 hasConcept C86803240 @default.
• W2022508149 hasConcept C95444343 @default.
• W2022508149 hasConceptScore W2022508149C104317684 @default.
• W2022508149 hasConceptScore W2022508149C11413529 @default.
• W2022508149 hasConceptScore W2022508149C119865680 @default.
• W2022508149 hasConceptScore W2022508149C169760540 @default.

• next