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- W2022508734 abstract "<h2>Abstract</h2> <i>Objective</i>: The increasing use of intravenous immunoglobulins (IVIg) to treat systemic inflammatory, mostly autoimmune, diseases raises the concern that their competition for FcγReceptor (FcγR) binding with immune complexes might interfere with the removal of opsonized microbial agents more than it favoured their opsonophagocytosis. <i>Methods</i>: Using a sensitive FACS-based phagocytosis assay allowing for the identification of the phagocytosing cell-type, we have tested the relative capacity of Pentaglobin® and two investigational IVIg preparations, IVIgG and IVIgM, to promote <i>E. coli</i> phagocytosis. The plasma IL-8 levels 4 h after phagocytosis were measured by ELISA. <i>Results</i>: Heat inactivated, complement (C) depleted serum allowed about 25% polymorphonuclear leukocytes (PMNLs) and 15% monocytes (MNs) of 16 donors to phagocyte <i>E. coli</i>. The addition of IVIg favoured mean phagocytosis by MNs to 55%, but by PMNLs only to 25%. The addition of fresh autologous plasma as a C source resulted in a boost of phagocytosing capacity to reach >90% of the PMNLs and >72% of the MNs. Blockade of FcγRII and FcγRI using monoclonal antibodies (mAb) reduced phagocytosis and IL-8 release. <i>Conclusion</i>: We conclude that excess IVIgG/M preparations added to a phagocytic system of PMNLs and MNs, without preopsonization of <i>E. coli</i>, promotes phagocytosis as expected, but MNs rather than PMNLs do this more thoroughly on their own." @default.
- W2022508734 created "2016-06-24" @default.
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- W2022508734 date "2001-08-01" @default.
- W2022508734 modified "2023-09-23" @default.
- W2022508734 title "Mononuclear cells ingest E. coli opsonized by investigational intravenous immunoglobulin preparations in the absence of complement more efficiently than polymorphonuclear phagocytes" @default.
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- W2022508734 doi "https://doi.org/10.1016/s1473-0502(01)00095-7" @default.
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