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- W2022509703 abstract "Melanin-concentrating hormone (MCH), a neuropeptide secreted by a limited number of neurons within the tuberal hypothalamus, has been drawn in the field of sleep only fairly recently in 2003. Since then, growing experimental evidence indicates that MCH may play a crucial role in the homeostatic regulation of paradoxical sleep (PS). MCH-expressing neurons fire specifically during PS. When injected icv MCH induces a 200% increase in PS quantities in rats and the lack of MCH induces a decrease in sleep quantities in transgenic mice. Here, we review recent studies suggesting a role for MCH in the regulation of the sleep–wake cycle, in particular PS, including insights on (1) the specific activity of MCH neurons during PS; (2) how they might be controlled across the sleep–wake cycle; (3) how they might modulate PS; (4) and finally whether MCH might take part in the expression of some symptoms observed in primary sleep disorders." @default.
- W2022509703 created "2016-06-24" @default.
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- W2022509703 creator A5020339568 @default.
- W2022509703 creator A5039821890 @default.
- W2022509703 creator A5043257734 @default.
- W2022509703 date "2009-11-01" @default.
- W2022509703 modified "2023-09-25" @default.
- W2022509703 title "Role of the melanin-concentrating hormone neuropeptide in sleep regulation" @default.
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- W2022509703 doi "https://doi.org/10.1016/j.peptides.2009.07.022" @default.
- W2022509703 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19660508" @default.
- W2022509703 hasPublicationYear "2009" @default.
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