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• W2022527777 abstract "The effects of the co-administration of the serotonin (5-HT) 1A receptor antagonists NAN-190 or (+)-WAY100135 with a selective 5-HT reuptake inhibitor (SSRI) citalopram on conditioned fear stress (CFS)-induced freezing behavior, which is the animal model of anxiety, were examined. The inhibitory effects of co-administration of NAN-190 (0.1–10 mg/kg) with citalopram on CFS-induced freezing were potent; in particular, at 0.1 and 0.25 mg/kg, NAN-190 significantly enhanced the effect of citalopram alone. At 0.1 mg/kg, (+)-WAY100135 also markedly enhanced the inhibitory effect of citalopram on freezing behavior. These findings suggest that 5-HT 1A receptor antagonist, particularly at low doses, enhances the antifreezing effect of citalopram by blocking the autoreceptor-mediated negative feedback mechanisms of the 5-HT neuron. These experimental results concur with clinical findings that 5-HT 1A receptor antagonist pindolol potentiates the effect of 5-HT reuptake inhibitors." @default.
• W2022527777 created "2016-06-24" @default.
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• W2022527777 date "1997-10-01" @default.
• W2022527777 modified "2023-09-23" @default.
• W2022527777 title "Effects of the Co-administration of 5-HT1A Receptor Antagonists with an SSRI in Conditioned Fear Stress-Induced Freezing Behavior" @default.
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• W2022527777 doi "https://doi.org/10.1016/s0091-3057(97)00008-7" @default.
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