FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022541225> ?p ?o ?g. }

• W2022541225 endingPage "452" @default.
• W2022541225 startingPage "446" @default.
• W2022541225 abstract "Soluble CD44 proteins generated by proteolytic cleavage or aberrant intron retention have been shown to antagonize the ligand binding activity of the corresponding cell surface receptor, inducing apoptosis and inhibiting tumor growth. Interestingly, such findings appear to contradict recent studies demonstrating a correlation between the presence of high levels of soluble CD44 in the serum of cancer patients and poor prognosis. In the present study, we report the cloning of a novel, naturally occurring, differentially expressed, soluble CD44 isoform, designated CD44RC, which, in contrast to previously described soluble CD44 proteins, can dramatically enhance the hyaluronan binding activity of cell surface CD44. Sequence analysis suggests that CD44RC is generated by an alternative splicing event in which the 3′ end of CD44 exon 2 is spliced into an internal splice acceptor site present within exon 18, altering reading frame and giving rise to a soluble protein with a unique COON terminus. Functional studies suggest that CD44RC enhances hyaluronan binding by adhering to chondroitin sulfate side-chains attached to cell surface CD44, generating a multivalent complex with increased avidity for hyaluronan." @default.
• W2022541225 created "2016-06-24" @default.
• W2022541225 creator A5004793531 @default.
• W2022541225 creator A5014753015 @default.
• W2022541225 creator A5031401366 @default.
• W2022541225 creator A5047355399 @default.
• W2022541225 creator A5060597026 @default.
• W2022541225 date "1999-11-01" @default.
• W2022541225 modified "2023-10-18" @default.
• W2022541225 title "Identification and Characterization of CD44RC, a Novel Alternatively Spliced Soluble CD44 Isoform that can Potentiate the Hyaluronan Binding Activity of Cell Surface CD44" @default.
• W2022541225 cites W101656022 @default.
• W2022541225 cites W1232240139 @default.
• W2022541225 cites W1558799097 @default.
• W2022541225 cites W1575205583 @default.
• W2022541225 cites W1603789301 @default.
• W2022541225 cites W1766367605 @default.
• W2022541225 cites W1849366664 @default.
• W2022541225 cites W1977684212 @default.
• W2022541225 cites W2000690705 @default.
• W2022541225 cites W2007479351 @default.
• W2022541225 cites W2018682645 @default.
• W2022541225 cites W2022243451 @default.
• W2022541225 cites W2031742143 @default.
• W2022541225 cites W2040388882 @default.
• W2022541225 cites W2057722822 @default.
• W2022541225 cites W2059177755 @default.
• W2022541225 cites W2061667408 @default.
• W2022541225 cites W2070614035 @default.
• W2022541225 cites W2071336621 @default.
• W2022541225 cites W2074684076 @default.
• W2022541225 cites W2079183637 @default.
• W2022541225 cites W2081578525 @default.
• W2022541225 cites W2084891010 @default.
• W2022541225 cites W2103771238 @default.
• W2022541225 cites W2117074787 @default.
• W2022541225 cites W2139521310 @default.
• W2022541225 cites W2313489220 @default.
• W2022541225 doi "https://doi.org/10.1038/sj.neo.7900045" @default.
• W2022541225 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1508116" @default.
• W2022541225 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10933060" @default.
• W2022541225 hasPublicationYear "1999" @default.
• W2022541225 type Work @default.
• W2022541225 sameAs 2022541225 @default.
• W2022541225 citedByCount "10" @default.
• W2022541225 countsByYear W20225412252013 @default.
• W2022541225 countsByYear W20225412252018 @default.
• W2022541225 countsByYear W20225412252021 @default.
• W2022541225 crossrefType "journal-article" @default.
• W2022541225 hasAuthorship W2022541225A5004793531 @default.
• W2022541225 hasAuthorship W2022541225A5014753015 @default.
• W2022541225 hasAuthorship W2022541225A5031401366 @default.
• W2022541225 hasAuthorship W2022541225A5047355399 @default.
• W2022541225 hasAuthorship W2022541225A5060597026 @default.
• W2022541225 hasBestOaLocation W20225412251 @default.
• W2022541225 hasConcept C104317684 @default.
• W2022541225 hasConcept C1491633281 @default.
• W2022541225 hasConcept C153074725 @default.
• W2022541225 hasConcept C153911025 @default.
• W2022541225 hasConcept C185592680 @default.
• W2022541225 hasConcept C194583182 @default.
• W2022541225 hasConcept C2779553658 @default.
• W2022541225 hasConcept C2780932548 @default.
• W2022541225 hasConcept C36823959 @default.
• W2022541225 hasConcept C53345823 @default.
• W2022541225 hasConcept C55493867 @default.
• W2022541225 hasConcept C86803240 @default.
• W2022541225 hasConcept C95444343 @default.
• W2022541225 hasConceptScore W2022541225C104317684 @default.
• W2022541225 hasConceptScore W2022541225C1491633281 @default.
• W2022541225 hasConceptScore W2022541225C153074725 @default.
• W2022541225 hasConceptScore W2022541225C153911025 @default.
• W2022541225 hasConceptScore W2022541225C185592680 @default.
• W2022541225 hasConceptScore W2022541225C194583182 @default.
• W2022541225 hasConceptScore W2022541225C2779553658 @default.
• W2022541225 hasConceptScore W2022541225C2780932548 @default.
• W2022541225 hasConceptScore W2022541225C36823959 @default.
• W2022541225 hasConceptScore W2022541225C53345823 @default.
• W2022541225 hasConceptScore W2022541225C55493867 @default.
• W2022541225 hasConceptScore W2022541225C86803240 @default.
• W2022541225 hasConceptScore W2022541225C95444343 @default.
• W2022541225 hasIssue "5" @default.
• W2022541225 hasLocation W20225412251 @default.
• W2022541225 hasLocation W20225412252 @default.
• W2022541225 hasLocation W20225412253 @default.
• W2022541225 hasLocation W20225412254 @default.
• W2022541225 hasLocation W20225412255 @default.
• W2022541225 hasOpenAccess W2022541225 @default.
• W2022541225 hasPrimaryLocation W20225412251 @default.
• W2022541225 hasRelatedWork W1991471725 @default.
• W2022541225 hasRelatedWork W1991703649 @default.
• W2022541225 hasRelatedWork W2006325063 @default.
• W2022541225 hasRelatedWork W2010473138 @default.
• W2022541225 hasRelatedWork W2042535624 @default.
• W2022541225 hasRelatedWork W2074215143 @default.
• W2022541225 hasRelatedWork W2081305715 @default.
• W2022541225 hasRelatedWork W2405804286 @default.
• W2022541225 hasRelatedWork W2470509493 @default.
• W2022541225 hasRelatedWork W4248980276 @default.

• next