FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022550311> ?p ?o ?g. }

• W2022550311 endingPage "2498" @default.
• W2022550311 startingPage "2489" @default.
• W2022550311 abstract "In this study, we investigated the anxiolytic-like effect of riluzole using three different innate anxiety models in rats. In the elevated plus-maze test, riluzole significantly increased the time spent in, and entries into, the open arm after 60 min administration. This finding was supported by results obtained from light/dark and open-field tests. The magnitude of the anxiolytic-like effects of riluzole in each of the behavioral models was similar to those produced by a benzodiazepine, diazepam, suggesting that riluzole has a robust anxiolytic-like activity in rats. To clarify the involvement of sodium channels in this anxiolytic activity, we examined the effect of a co-administered sodium channel activator, veratrine. The anxiolytic-like action of riluzole was diminished by veratrine in the elevated plus-maze, light/dark and open-field tests. Based on these results, it is suggested that the anxiolytic mechanism of riluzole is clearly distinct from that of diazepam. In addition, to examine whether riluzole directly and non-selectively affected the GABAA-benzodiazepine receptor complex, we performed three behavioral tests (footprint analysis, Y-maze test and the ethanol-induced sleeping time test) that are closely related to the GABAA-benzodiazepine pathways. In contrast to diazepam, riluzole produced no significant effects in these tests. Here, we provide the first report demonstrating that riluzole produces distinct anxiolytic-like effects in rats without the adverse effects associated with benzodiazepines." @default.
• W2022550311 created "2016-06-24" @default.
• W2022550311 creator A5032585641 @default.
• W2022550311 creator A5045407705 @default.
• W2022550311 creator A5053429229 @default.
• W2022550311 creator A5060826211 @default.
• W2022550311 creator A5060895352 @default.
• W2022550311 creator A5068736197 @default.
• W2022550311 creator A5075385695 @default.
• W2022550311 creator A5076261034 @default.
• W2022550311 date "2012-06-01" @default.
• W2022550311 modified "2023-09-26" @default.
• W2022550311 title "Riluzole produces distinct anxiolytic-like effects in rats without the adverse effects associated with benzodiazepines" @default.
• W2022550311 cites W1503832746 @default.
• W2022550311 cites W1966385194 @default.
• W2022550311 cites W1966429600 @default.
• W2022550311 cites W1966837740 @default.
• W2022550311 cites W1967308562 @default.
• W2022550311 cites W1968533747 @default.
• W2022550311 cites W1968828764 @default.
• W2022550311 cites W1970076964 @default.
• W2022550311 cites W1972825247 @default.
• W2022550311 cites W1975831875 @default.
• W2022550311 cites W1979456296 @default.
• W2022550311 cites W1982538263 @default.
• W2022550311 cites W1983568884 @default.
• W2022550311 cites W1984518477 @default.
• W2022550311 cites W1985441860 @default.
• W2022550311 cites W1986569661 @default.
• W2022550311 cites W1993097947 @default.
• W2022550311 cites W1996354222 @default.
• W2022550311 cites W2006960210 @default.
• W2022550311 cites W2010526028 @default.
• W2022550311 cites W2020726187 @default.
• W2022550311 cites W2021723085 @default.
• W2022550311 cites W2022700331 @default.
• W2022550311 cites W2024077111 @default.
• W2022550311 cites W2027350487 @default.
• W2022550311 cites W2034199785 @default.
• W2022550311 cites W2039961483 @default.
• W2022550311 cites W2041561931 @default.
• W2022550311 cites W2044585897 @default.
• W2022550311 cites W2046478987 @default.
• W2022550311 cites W2046589688 @default.
• W2022550311 cites W2051263750 @default.
• W2022550311 cites W2054658320 @default.
• W2022550311 cites W2056001429 @default.
• W2022550311 cites W2059122691 @default.
• W2022550311 cites W2067032426 @default.
• W2022550311 cites W2067702715 @default.
• W2022550311 cites W2068449302 @default.
• W2022550311 cites W2069314031 @default.
• W2022550311 cites W2069544569 @default.
• W2022550311 cites W2069643849 @default.
• W2022550311 cites W2072807884 @default.
• W2022550311 cites W2075262044 @default.
• W2022550311 cites W2081938027 @default.
• W2022550311 cites W2091855875 @default.
• W2022550311 cites W2137992068 @default.
• W2022550311 cites W2153606400 @default.
• W2022550311 cites W2159851687 @default.
• W2022550311 cites W2165420548 @default.
• W2022550311 cites W4256575336 @default.
• W2022550311 cites W96071114 @default.
• W2022550311 doi "https://doi.org/10.1016/j.neuropharm.2012.02.012" @default.
• W2022550311 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22377384" @default.
• W2022550311 hasPublicationYear "2012" @default.
• W2022550311 type Work @default.
• W2022550311 sameAs 2022550311 @default.
• W2022550311 citedByCount "35" @default.
• W2022550311 countsByYear W20225503112012 @default.
• W2022550311 countsByYear W20225503112013 @default.
• W2022550311 countsByYear W20225503112014 @default.
• W2022550311 countsByYear W20225503112015 @default.
• W2022550311 countsByYear W20225503112016 @default.
• W2022550311 countsByYear W20225503112017 @default.
• W2022550311 countsByYear W20225503112018 @default.
• W2022550311 countsByYear W20225503112019 @default.
• W2022550311 countsByYear W20225503112020 @default.
• W2022550311 countsByYear W20225503112021 @default.
• W2022550311 countsByYear W20225503112022 @default.
• W2022550311 countsByYear W20225503112023 @default.
• W2022550311 crossrefType "journal-article" @default.
• W2022550311 hasAuthorship W2022550311A5032585641 @default.
• W2022550311 hasAuthorship W2022550311A5045407705 @default.
• W2022550311 hasAuthorship W2022550311A5053429229 @default.
• W2022550311 hasAuthorship W2022550311A5060826211 @default.
• W2022550311 hasAuthorship W2022550311A5060895352 @default.
• W2022550311 hasAuthorship W2022550311A5068736197 @default.
• W2022550311 hasAuthorship W2022550311A5075385695 @default.
• W2022550311 hasAuthorship W2022550311A5076261034 @default.
• W2022550311 hasConcept C118552586 @default.
• W2022550311 hasConcept C126322002 @default.
• W2022550311 hasConcept C168258287 @default.
• W2022550311 hasConcept C170493617 @default.
• W2022550311 hasConcept C173586616 @default.
• W2022550311 hasConcept C185592680 @default.
• W2022550311 hasConcept C2776175493 @default.

• next