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• W2022551878 abstract "We have synthesized and evaluated a series of novel HCV NS3 protease inhibitors with various P4 capping groups, which include urea, carbamate, methoxy-carboxamide, cyclic carbamate and amide, pyruvic amide, oxamate, oxalamide and cyanoguanidine. Most of these compounds are remarkably potent, exhibiting single-digit to sub-nanomolar activity in the enzyme assay and cell-based replicon assay. Selected compounds were also evaluated in the protease-inhibitor-resistant mutant transient replicon assay, and they were found to show quite different potency profiles against a panel of HCV protease-inhibitor-resistant mutants." @default.
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• W2022551878 date "2012-12-01" @default.
• W2022551878 modified "2023-09-22" @default.
• W2022551878 title "Synthesis and antiviral activity of novel HCV NS3 protease inhibitors with P4 capping groups" @default.
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• W2022551878 doi "https://doi.org/10.1016/j.bmcl.2012.10.075" @default.
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