Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022553578> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W2022553578 abstract "We have tested the calmodulin (CaM) inhibitory potency of class I antiarrhythmics in the phosphodiesterase (PDE) assay. The lipophilicity of the test compounds has been quantified by two experimental (log P, RM) and two calculative (sigma f, C log P) procedures. Five antiarrhythmics (asocainol, aprindine, lorcainide, propafenone, and ethmozine) exhibit IC50 values less than 250 microM for the inhibition of the CaM-stimulated PDE activity. Lipophilicity seems to be a prime, but not the sole descriptor of CaM inhibitory potency. The functional means of CaM inhibition by the test compounds for their antiarrhythmic properties remains to be clarified in further investigations." @default.
- W2022553578 created "2016-06-24" @default.
- W2022553578 creator A5048523924 @default.
- W2022553578 creator A5052558608 @default.
- W2022553578 creator A5084729994 @default.
- W2022553578 creator A5089643547 @default.
- W2022553578 date "1990-01-01" @default.
- W2022553578 modified "2023-09-27" @default.
- W2022553578 title "Molecular Pharmacological Aspects of Antiarrhythmic Activity, II1): Interaction of Class I Compounds with Calmodulin" @default.
- W2022553578 cites W1978177616 @default.
- W2022553578 cites W2003906664 @default.
- W2022553578 cites W2009846810 @default.
- W2022553578 cites W2029670216 @default.
- W2022553578 cites W2036136583 @default.
- W2022553578 cites W2046934913 @default.
- W2022553578 cites W2055584700 @default.
- W2022553578 cites W2079745408 @default.
- W2022553578 cites W2091229989 @default.
- W2022553578 cites W2092315848 @default.
- W2022553578 cites W2094373300 @default.
- W2022553578 cites W2162756399 @default.
- W2022553578 cites W2168564324 @default.
- W2022553578 cites W335971509 @default.
- W2022553578 doi "https://doi.org/10.1002/ardp.19903230809" @default.
- W2022553578 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2278515" @default.
- W2022553578 hasPublicationYear "1990" @default.
- W2022553578 type Work @default.
- W2022553578 sameAs 2022553578 @default.
- W2022553578 citedByCount "4" @default.
- W2022553578 countsByYear W20225535782020 @default.
- W2022553578 crossrefType "journal-article" @default.
- W2022553578 hasAuthorship W2022553578A5048523924 @default.
- W2022553578 hasAuthorship W2022553578A5052558608 @default.
- W2022553578 hasAuthorship W2022553578A5084729994 @default.
- W2022553578 hasAuthorship W2022553578A5089643547 @default.
- W2022553578 hasConcept C126322002 @default.
- W2022553578 hasConcept C17077164 @default.
- W2022553578 hasConcept C181199279 @default.
- W2022553578 hasConcept C185592680 @default.
- W2022553578 hasConcept C201399114 @default.
- W2022553578 hasConcept C202751555 @default.
- W2022553578 hasConcept C2777752497 @default.
- W2022553578 hasConcept C2779161974 @default.
- W2022553578 hasConcept C2781472538 @default.
- W2022553578 hasConcept C29688787 @default.
- W2022553578 hasConcept C55493867 @default.
- W2022553578 hasConcept C57992300 @default.
- W2022553578 hasConcept C62826618 @default.
- W2022553578 hasConcept C71240020 @default.
- W2022553578 hasConcept C71924100 @default.
- W2022553578 hasConcept C86803240 @default.
- W2022553578 hasConcept C98274493 @default.
- W2022553578 hasConceptScore W2022553578C126322002 @default.
- W2022553578 hasConceptScore W2022553578C17077164 @default.
- W2022553578 hasConceptScore W2022553578C181199279 @default.
- W2022553578 hasConceptScore W2022553578C185592680 @default.
- W2022553578 hasConceptScore W2022553578C201399114 @default.
- W2022553578 hasConceptScore W2022553578C202751555 @default.
- W2022553578 hasConceptScore W2022553578C2777752497 @default.
- W2022553578 hasConceptScore W2022553578C2779161974 @default.
- W2022553578 hasConceptScore W2022553578C2781472538 @default.
- W2022553578 hasConceptScore W2022553578C29688787 @default.
- W2022553578 hasConceptScore W2022553578C55493867 @default.
- W2022553578 hasConceptScore W2022553578C57992300 @default.
- W2022553578 hasConceptScore W2022553578C62826618 @default.
- W2022553578 hasConceptScore W2022553578C71240020 @default.
- W2022553578 hasConceptScore W2022553578C71924100 @default.
- W2022553578 hasConceptScore W2022553578C86803240 @default.
- W2022553578 hasConceptScore W2022553578C98274493 @default.
- W2022553578 hasLocation W20225535781 @default.
- W2022553578 hasLocation W20225535782 @default.
- W2022553578 hasOpenAccess W2022553578 @default.
- W2022553578 hasPrimaryLocation W20225535781 @default.
- W2022553578 hasRelatedWork W1969592663 @default.
- W2022553578 hasRelatedWork W1986935641 @default.
- W2022553578 hasRelatedWork W1989937470 @default.
- W2022553578 hasRelatedWork W2022553578 @default.
- W2022553578 hasRelatedWork W2081425390 @default.
- W2022553578 hasRelatedWork W2417389632 @default.
- W2022553578 hasRelatedWork W2525009904 @default.
- W2022553578 hasRelatedWork W2801012012 @default.
- W2022553578 hasRelatedWork W3180019265 @default.
- W2022553578 hasRelatedWork W79387094 @default.
- W2022553578 isParatext "false" @default.
- W2022553578 isRetracted "false" @default.
- W2022553578 magId "2022553578" @default.
- W2022553578 workType "article" @default.