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• W2022554438 endingPage "480" @default.
• W2022554438 startingPage "468" @default.
• W2022554438 abstract "Abstract Background Gastrointestinal ( GI ) dysfunction is a major cause of morbidity in acquired immunodeficiency syndrome (AIDS). HIV ‐1‐induced neuropathogenesis is significantly enhanced by opiate abuse, which increases proinflammatory chemokine/cytokine release, the production of reactive species, glial reactivity, and neuronal injury in the central nervous system. Despite marked interactions in the gut, little is known about the effects of HIV ‐1 in combination with opiate use on the enteric nervous system. Methods To explore HIV ‐opiate interactions in myenteric neurons, the effects of Tat ± morphine (0.03, 0.3, and 3 μ M) were examined in isolated neurons from doxycycline‐ ( DOX ‐) inducible HIV ‐1 Tat 1‐86 transgenic mice or following in vitro Tat 100 nM exposure (>6 h). Key Results Current clamp recordings demonstrated increased neuronal excitability in neurons of inducible Tat(+) mice (Tat+/ DOX ) compared to control Tat−/ DOX mice. In neurons from Tat+/ DOX , but not from Tat−/ DOX mice, 0.03 μ M morphine significantly reduced neuronal excitability, fast transient and late long‐lasting sodium currents. There was a significant leftward shift in V 0.5 of inactivation following exposure to 0.03 μ M morphine, with a 50% decrease in availability of sodium channels at −100 mV. Similar effects were noted with in vitro Tat exposure in the presence of 0.3 μ M morphine. Additionally, GI motility was significantly more sensitive to morphine in Tat(+) mice than Tat(−) mice. Conclusions & Inferences Overall, these data suggest that the sensitivity of enteric neurons to morphine is enhanced in the presence of Tat. Opiates and HIV ‐1 may uniquely interact to exacerbate the deleterious effects of HIV ‐1‐infection and opiate exposure on GI function." @default.
• W2022554438 created "2016-06-24" @default.
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• W2022554438 date "2015-02-19" @default.
• W2022554438 modified "2023-10-03" @default.
• W2022554438 title "Sensitization of enteric neurons to morphine by HIV-1 Tat protein" @default.
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• W2022554438 cites W1519695565 @default.
• W2022554438 cites W1557565519 @default.
• W2022554438 cites W1581091695 @default.
• W2022554438 cites W1823836002 @default.
• W2022554438 cites W1866441837 @default.
• W2022554438 cites W19464692 @default.
• W2022554438 cites W1964092216 @default.
• W2022554438 cites W1965786497 @default.
• W2022554438 cites W1971091888 @default.
• W2022554438 cites W1971414844 @default.
• W2022554438 cites W1973535106 @default.
• W2022554438 cites W1973640136 @default.
• W2022554438 cites W1974747011 @default.
• W2022554438 cites W1975456780 @default.
• W2022554438 cites W1976434061 @default.
• W2022554438 cites W1978216823 @default.
• W2022554438 cites W1979633031 @default.
• W2022554438 cites W1983737585 @default.
• W2022554438 cites W1989354537 @default.
• W2022554438 cites W1993264471 @default.
• W2022554438 cites W1995746794 @default.
• W2022554438 cites W1996476108 @default.
• W2022554438 cites W1998529637 @default.
• W2022554438 cites W1999613356 @default.
• W2022554438 cites W2000250827 @default.
• W2022554438 cites W2003545714 @default.
• W2022554438 cites W2005015878 @default.
• W2022554438 cites W2006905904 @default.
• W2022554438 cites W2016912297 @default.
• W2022554438 cites W2017486089 @default.
• W2022554438 cites W2020975582 @default.
• W2022554438 cites W2026923916 @default.
• W2022554438 cites W2032529775 @default.
• W2022554438 cites W2035418780 @default.
• W2022554438 cites W2041910698 @default.
• W2022554438 cites W2044887735 @default.
• W2022554438 cites W2051309246 @default.
• W2022554438 cites W2054869385 @default.
• W2022554438 cites W2059095114 @default.
• W2022554438 cites W2061845693 @default.
• W2022554438 cites W2062012741 @default.
• W2022554438 cites W2064172449 @default.
• W2022554438 cites W2066016541 @default.
• W2022554438 cites W2067550112 @default.
• W2022554438 cites W2067588654 @default.
• W2022554438 cites W2073432419 @default.
• W2022554438 cites W2074029198 @default.
• W2022554438 cites W2075525256 @default.
• W2022554438 cites W2084251620 @default.
• W2022554438 cites W2087125815 @default.
• W2022554438 cites W2087401145 @default.
• W2022554438 cites W2091284200 @default.
• W2022554438 cites W2095083924 @default.
• W2022554438 cites W2105772032 @default.
• W2022554438 cites W2106973613 @default.
• W2022554438 cites W2111392394 @default.
• W2022554438 cites W2113408846 @default.
• W2022554438 cites W2113466274 @default.
• W2022554438 cites W2125202557 @default.
• W2022554438 cites W2126718411 @default.
• W2022554438 cites W2130599091 @default.
• W2022554438 cites W2134451487 @default.
• W2022554438 cites W2138294676 @default.
• W2022554438 cites W2142529927 @default.
• W2022554438 cites W2144264095 @default.
• W2022554438 cites W2147151936 @default.
• W2022554438 cites W2150871111 @default.
• W2022554438 cites W2155134319 @default.
• W2022554438 cites W2166174026 @default.
• W2022554438 cites W2170457399 @default.
• W2022554438 cites W2311408641 @default.
• W2022554438 cites W2339953034 @default.
• W2022554438 cites W4254848357 @default.
• W2022554438 cites W65240709 @default.
• W2022554438 doi "https://doi.org/10.1111/nmo.12514" @default.
• W2022554438 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4380805" @default.
• W2022554438 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25703354" @default.
• W2022554438 hasPublicationYear "2015" @default.
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