FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022554562> ?p ?o ?g. }

• W2022554562 endingPage "48" @default.
• W2022554562 startingPage "37" @default.
• W2022554562 abstract "Secretion in the obligate intracellular parasite, Toxoplasma gondii, occurs through a number of regulated compartments. Among these are the apical organelles known as rhoptries which release their contents as part of the invasion process. We are interested in the processing, targeting and ultimate function of rhoptry proteins (and have focused our analyses on rhoptry protein 1 (ROP1). In this paper, we address the issue of processing: using a number of engineered forms of the ROP1 gene (introduced into a ROP1− background), we show that ROP1 is synthesized as a pre-pro-protein that is subject to proteolytic cleavages to remove the pre-sequence and the ‘pro’ region, at the N-terminus. Using brefeldin A (BFA) and reduced temperature we show that this processing occurs late in the secretory pathway of the parasite. Immunolocalization studies with epitope-tagged constructs indicate that processing is apparently occurring in the nascent rhoptries of dividing parasites. The results are discussed in the context of the targeting and possible function of the ROP1 protein." @default.
• W2022554562 created "2016-06-24" @default.
• W2022554562 creator A5001715925 @default.
• W2022554562 creator A5020395108 @default.
• W2022554562 creator A5053925806 @default.
• W2022554562 creator A5082233068 @default.
• W2022554562 date "1998-10-01" @default.
• W2022554562 modified "2023-09-27" @default.
• W2022554562 title "Processing of Toxoplasma ROP1 protein in nascent rhoptries" @default.
• W2022554562 cites W1826524642 @default.
• W2022554562 cites W1838108008 @default.
• W2022554562 cites W1935488287 @default.
• W2022554562 cites W1966503629 @default.
• W2022554562 cites W1976578327 @default.
• W2022554562 cites W1977693553 @default.
• W2022554562 cites W1987335498 @default.
• W2022554562 cites W1998615549 @default.
• W2022554562 cites W2000861996 @default.
• W2022554562 cites W2014411987 @default.
• W2022554562 cites W2029410606 @default.
• W2022554562 cites W2034746871 @default.
• W2022554562 cites W2052537022 @default.
• W2022554562 cites W2058172718 @default.
• W2022554562 cites W2071534681 @default.
• W2022554562 cites W2073695321 @default.
• W2022554562 cites W2088819006 @default.
• W2022554562 cites W2100837269 @default.
• W2022554562 cites W2101898282 @default.
• W2022554562 cites W2107312415 @default.
• W2022554562 cites W2138006485 @default.
• W2022554562 doi "https://doi.org/10.1016/s0166-6851(98)00090-5" @default.
• W2022554562 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9851605" @default.
• W2022554562 hasPublicationYear "1998" @default.
• W2022554562 type Work @default.
• W2022554562 sameAs 2022554562 @default.
• W2022554562 citedByCount "92" @default.
• W2022554562 countsByYear W20225545622012 @default.
• W2022554562 countsByYear W20225545622013 @default.
• W2022554562 countsByYear W20225545622014 @default.
• W2022554562 countsByYear W20225545622015 @default.
• W2022554562 countsByYear W20225545622017 @default.
• W2022554562 countsByYear W20225545622018 @default.
• W2022554562 countsByYear W20225545622019 @default.
• W2022554562 countsByYear W20225545622020 @default.
• W2022554562 countsByYear W20225545622022 @default.
• W2022554562 countsByYear W20225545622023 @default.
• W2022554562 crossrefType "journal-article" @default.
• W2022554562 hasAuthorship W2022554562A5001715925 @default.
• W2022554562 hasAuthorship W2022554562A5020395108 @default.
• W2022554562 hasAuthorship W2022554562A5053925806 @default.
• W2022554562 hasAuthorship W2022554562A5082233068 @default.
• W2022554562 hasConcept C119062480 @default.
• W2022554562 hasConcept C151730666 @default.
• W2022554562 hasConcept C158617107 @default.
• W2022554562 hasConcept C159654299 @default.
• W2022554562 hasConcept C168240541 @default.
• W2022554562 hasConcept C203014093 @default.
• W2022554562 hasConcept C24990904 @default.
• W2022554562 hasConcept C2778048844 @default.
• W2022554562 hasConcept C2778128430 @default.
• W2022554562 hasConcept C2778371730 @default.
• W2022554562 hasConcept C2779343474 @default.
• W2022554562 hasConcept C2781023229 @default.
• W2022554562 hasConcept C2781295650 @default.
• W2022554562 hasConcept C2781373781 @default.
• W2022554562 hasConcept C40602308 @default.
• W2022554562 hasConcept C49039625 @default.
• W2022554562 hasConcept C54355233 @default.
• W2022554562 hasConcept C55493867 @default.
• W2022554562 hasConcept C59822182 @default.
• W2022554562 hasConcept C86803240 @default.
• W2022554562 hasConcept C95444343 @default.
• W2022554562 hasConceptScore W2022554562C119062480 @default.
• W2022554562 hasConceptScore W2022554562C151730666 @default.
• W2022554562 hasConceptScore W2022554562C158617107 @default.
• W2022554562 hasConceptScore W2022554562C159654299 @default.
• W2022554562 hasConceptScore W2022554562C168240541 @default.
• W2022554562 hasConceptScore W2022554562C203014093 @default.
• W2022554562 hasConceptScore W2022554562C24990904 @default.
• W2022554562 hasConceptScore W2022554562C2778048844 @default.
• W2022554562 hasConceptScore W2022554562C2778128430 @default.
• W2022554562 hasConceptScore W2022554562C2778371730 @default.
• W2022554562 hasConceptScore W2022554562C2779343474 @default.
• W2022554562 hasConceptScore W2022554562C2781023229 @default.
• W2022554562 hasConceptScore W2022554562C2781295650 @default.
• W2022554562 hasConceptScore W2022554562C2781373781 @default.
• W2022554562 hasConceptScore W2022554562C40602308 @default.
• W2022554562 hasConceptScore W2022554562C49039625 @default.
• W2022554562 hasConceptScore W2022554562C54355233 @default.
• W2022554562 hasConceptScore W2022554562C55493867 @default.
• W2022554562 hasConceptScore W2022554562C59822182 @default.
• W2022554562 hasConceptScore W2022554562C86803240 @default.
• W2022554562 hasConceptScore W2022554562C95444343 @default.
• W2022554562 hasIssue "1-2" @default.
• W2022554562 hasLocation W20225545621 @default.
• W2022554562 hasLocation W20225545622 @default.
• W2022554562 hasOpenAccess W2022554562 @default.
• W2022554562 hasPrimaryLocation W20225545621 @default.

• next