Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022556398> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W2022556398 endingPage "76" @default.
- W2022556398 startingPage "71" @default.
- W2022556398 abstract "Outer hair cells (OHCs) of the inner ear rapidly convert electrical gradients into mechanical force, enhancing cochlear sensitivity and frequency selectivity. We investigated the effect of chlorpromazine, an antipsychotic medication that alters membrane biomechanics, on OHC electromotility.Isolated guinea pig outer hair cells were perfused with chlorpromazine under whole-cell patch-pipette recording conditions. Electromotile responses were measured.A dramatic, reversible, dose-dependent depolarization of voltage at peak capacitance (V(pkCm)) was seen with chlorpromazine treatment. The gain of the electromotile response was maximal near V(pkCm) both before and after chlorpromazine application. Unlike the 3 other agents that alter electromotility (salicylate, lanthanides, membrane tension), chlorpromazine did not change peak capacitance (Cm(pk)), which varies directly with maximal electromotile gain.Chlorpromazine changes the membrane voltage at which OHCs exhibit maximal electromotile gain, without changing the magnitude of electromotile responses.Chlorpromazine may diminish hearing thresholds or otoacoustic emissions in large doses." @default.
- W2022556398 created "2016-06-24" @default.
- W2022556398 creator A5036557880 @default.
- W2022556398 creator A5039680912 @default.
- W2022556398 creator A5071139845 @default.
- W2022556398 date "2001-07-01" @default.
- W2022556398 modified "2023-09-27" @default.
- W2022556398 title "Chlorpromazine Alters Outer Hair Cell Electromotility" @default.
- W2022556398 cites W1554225425 @default.
- W2022556398 cites W1828005955 @default.
- W2022556398 cites W1979856671 @default.
- W2022556398 cites W1984054735 @default.
- W2022556398 cites W2013030459 @default.
- W2022556398 cites W2017786805 @default.
- W2022556398 cites W2027966172 @default.
- W2022556398 cites W2028016924 @default.
- W2022556398 cites W2036708962 @default.
- W2022556398 cites W2038717281 @default.
- W2022556398 cites W2040359401 @default.
- W2022556398 cites W2059938754 @default.
- W2022556398 cites W2069225430 @default.
- W2022556398 cites W2069293641 @default.
- W2022556398 cites W2070129920 @default.
- W2022556398 cites W2074276238 @default.
- W2022556398 cites W2084011431 @default.
- W2022556398 cites W2120778711 @default.
- W2022556398 cites W2157194890 @default.
- W2022556398 doi "https://doi.org/10.1067/mhn.2001.116446" @default.
- W2022556398 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11458218" @default.
- W2022556398 hasPublicationYear "2001" @default.
- W2022556398 type Work @default.
- W2022556398 sameAs 2022556398 @default.
- W2022556398 citedByCount "30" @default.
- W2022556398 countsByYear W20225563982013 @default.
- W2022556398 countsByYear W20225563982017 @default.
- W2022556398 crossrefType "journal-article" @default.
- W2022556398 hasAuthorship W2022556398A5036557880 @default.
- W2022556398 hasAuthorship W2022556398A5039680912 @default.
- W2022556398 hasAuthorship W2022556398A5071139845 @default.
- W2022556398 hasConcept C105702510 @default.
- W2022556398 hasConcept C12554922 @default.
- W2022556398 hasConcept C126322002 @default.
- W2022556398 hasConcept C181911157 @default.
- W2022556398 hasConcept C185592680 @default.
- W2022556398 hasConcept C2778585322 @default.
- W2022556398 hasConcept C2778775820 @default.
- W2022556398 hasConcept C2780130748 @default.
- W2022556398 hasConcept C2780898785 @default.
- W2022556398 hasConcept C2908762784 @default.
- W2022556398 hasConcept C4141045 @default.
- W2022556398 hasConcept C71924100 @default.
- W2022556398 hasConcept C86803240 @default.
- W2022556398 hasConceptScore W2022556398C105702510 @default.
- W2022556398 hasConceptScore W2022556398C12554922 @default.
- W2022556398 hasConceptScore W2022556398C126322002 @default.
- W2022556398 hasConceptScore W2022556398C181911157 @default.
- W2022556398 hasConceptScore W2022556398C185592680 @default.
- W2022556398 hasConceptScore W2022556398C2778585322 @default.
- W2022556398 hasConceptScore W2022556398C2778775820 @default.
- W2022556398 hasConceptScore W2022556398C2780130748 @default.
- W2022556398 hasConceptScore W2022556398C2780898785 @default.
- W2022556398 hasConceptScore W2022556398C2908762784 @default.
- W2022556398 hasConceptScore W2022556398C4141045 @default.
- W2022556398 hasConceptScore W2022556398C71924100 @default.
- W2022556398 hasConceptScore W2022556398C86803240 @default.
- W2022556398 hasIssue "1" @default.
- W2022556398 hasLocation W20225563981 @default.
- W2022556398 hasLocation W20225563982 @default.
- W2022556398 hasOpenAccess W2022556398 @default.
- W2022556398 hasPrimaryLocation W20225563981 @default.
- W2022556398 hasRelatedWork W1534748065 @default.
- W2022556398 hasRelatedWork W1583482231 @default.
- W2022556398 hasRelatedWork W1964532154 @default.
- W2022556398 hasRelatedWork W2009296295 @default.
- W2022556398 hasRelatedWork W2031581165 @default.
- W2022556398 hasRelatedWork W2062605550 @default.
- W2022556398 hasRelatedWork W2068327182 @default.
- W2022556398 hasRelatedWork W2090959387 @default.
- W2022556398 hasRelatedWork W2100547704 @default.
- W2022556398 hasRelatedWork W2148100095 @default.
- W2022556398 hasVolume "125" @default.
- W2022556398 isParatext "false" @default.
- W2022556398 isRetracted "false" @default.
- W2022556398 magId "2022556398" @default.
- W2022556398 workType "article" @default.