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- W2022562497 abstract "The aim of this work is to evaluate the antioxidative activity of antimetastatic agent pentoxifylline (PTX) in B16F10 and B16F1 melanoma cells.B16F10 and B16F1 cell lines were treated with PTX with different doses at different time intervals. Reduced glutathione, glutathione-S-transferase, and lipid peroxides were estimated to evaluate the action of PTX.The activity of pentoxifylline treatment showed glutathione depletion, increased glutathione-S-transferase activity with upregulation of lipid peroxidation in B16F10 and B16F1 melanoma cells. However, the effect on GSH, GST, and LPOs was dependent on dose concentrations and time intervals.Pentoxifylline, an effective membrane modifier, showed significant depletion in glutathione level in conjunction with increased lipid peroxidation. The results suggested an antimetastatic property by PTX at a nontoxic dose in B16F10 and B16F1 melanoma cells." @default.
- W2022562497 created "2016-06-24" @default.
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- W2022562497 date "2003-08-01" @default.
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- W2022562497 title "Potentiation of Antimetastatic Activity of Pentoxifylline in B16F10 and B16F1 Melanoma Cells Through Inhibition of Glutathione Content" @default.
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- W2022562497 doi "https://doi.org/10.1089/108497803322287637" @default.
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