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- W2022577659 abstract "ketamine, ketorolac nor tramadol altered tolerance time but in buprenorphine subjects, morphine with either ketamine or tramadol increased tolerance times by 22 and 40%, respectively. Conclusions: Hyperalgesia can be measured by the cold pressor test in patients taking opioids for a variety of indications. Chronic opioid administration not only causes tolerance but also increases pain sensitivity leading to opioid-induced hyperalgesia without allodynia. The mechanism(s) are poorly understood, appear not to be opioid drug or dosing regimen specific but may involve immune system modulators. Novel therapeutic strategies are therefore required for the management of persistent pain in patients receiving opioids that can attenuate hyperalgesia without causing additional or new adverse effects. The future will likely see combinations of analgesics and antihyperalgesics. Acknowledgement: the research was supported by grants from NIH (USA) and NHMRC(Australia)." @default.
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- W2022577659 date "2009-05-01" @default.
- W2022577659 modified "2023-09-23" @default.
- W2022577659 title "I20 What makes a chronic pain patient?" @default.
- W2022577659 doi "https://doi.org/10.1016/s1877-8860(09)70026-6" @default.
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