Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022585532> ?p ?o ?g. }
- W2022585532 endingPage "972" @default.
- W2022585532 startingPage "963" @default.
- W2022585532 abstract "Abstract CX3CR1 is a chemokine receptor with a single ligand, the membrane-tethered chemokine CX3CL1 (fractalkine). All blood monocytes express CX3CR1, but its levels differ between the main 2 subsets, with human CD16+ and murine Gr1low monocytes being CX3CR1hi. Here, we report that absence of either CX3CR1 or CX3CL1 results in a significant reduction of Gr1low blood monocyte levels under both steady-state and inflammatory conditions. Introduction of a Bcl2 transgene restored the wild-type phenotype, suggesting that the CX3C axis provides an essential survival signal. Supporting this notion, we show that CX3CL1 specifically rescues cultured human monocytes from induced cell death. Human CX3CR1 gene polymorphisms are risk factors for atherosclerosis and mice deficient for the CX3C receptor or ligand are relatively protected from atherosclerosis development. However, the mechanistic role of CX3CR1 in atherogenesis remains unclear. Here, we show that enforced survival of monocytes and plaque-resident phagocytes, including foam cells, restored atherogenesis in CX3CR1-deficent mice. The fact that CX3CL1-CX3CR1 interactions confer an essential survival signal, whose absence leads to increased death of monocytes and/or foam cells, might provide a mechanistic explanation for the role of the CX3C chemokine family in atherogenesis." @default.
- W2022585532 created "2016-06-24" @default.
- W2022585532 creator A5001883769 @default.
- W2022585532 creator A5011728393 @default.
- W2022585532 creator A5017760830 @default.
- W2022585532 creator A5030330623 @default.
- W2022585532 creator A5038597248 @default.
- W2022585532 creator A5054998121 @default.
- W2022585532 creator A5082894731 @default.
- W2022585532 creator A5085435142 @default.
- W2022585532 creator A5085718942 @default.
- W2022585532 creator A5091554690 @default.
- W2022585532 date "2009-01-22" @default.
- W2022585532 modified "2023-09-30" @default.
- W2022585532 title "CX3CR1 is required for monocyte homeostasis and atherogenesis by promoting cell survival" @default.
- W2022585532 cites W1506086660 @default.
- W2022585532 cites W1652900453 @default.
- W2022585532 cites W1834820177 @default.
- W2022585532 cites W1977109672 @default.
- W2022585532 cites W1978992492 @default.
- W2022585532 cites W1982890244 @default.
- W2022585532 cites W1984115097 @default.
- W2022585532 cites W1985502949 @default.
- W2022585532 cites W1990078228 @default.
- W2022585532 cites W1991026693 @default.
- W2022585532 cites W1995095891 @default.
- W2022585532 cites W1996866382 @default.
- W2022585532 cites W2008669330 @default.
- W2022585532 cites W2011363498 @default.
- W2022585532 cites W2015141049 @default.
- W2022585532 cites W2026578487 @default.
- W2022585532 cites W2027521196 @default.
- W2022585532 cites W2028841673 @default.
- W2022585532 cites W2029174607 @default.
- W2022585532 cites W2034175553 @default.
- W2022585532 cites W2046673854 @default.
- W2022585532 cites W2048890665 @default.
- W2022585532 cites W2052554962 @default.
- W2022585532 cites W2052615997 @default.
- W2022585532 cites W2053577903 @default.
- W2022585532 cites W2058383884 @default.
- W2022585532 cites W2063699877 @default.
- W2022585532 cites W2065577210 @default.
- W2022585532 cites W2066963386 @default.
- W2022585532 cites W2070590745 @default.
- W2022585532 cites W2088024377 @default.
- W2022585532 cites W2096179876 @default.
- W2022585532 cites W2099625699 @default.
- W2022585532 cites W2103911019 @default.
- W2022585532 cites W2104899502 @default.
- W2022585532 cites W2105489252 @default.
- W2022585532 cites W2106274007 @default.
- W2022585532 cites W2109997080 @default.
- W2022585532 cites W2115457290 @default.
- W2022585532 cites W2120280279 @default.
- W2022585532 cites W2124984983 @default.
- W2022585532 cites W2126972955 @default.
- W2022585532 cites W2132271411 @default.
- W2022585532 cites W2132852509 @default.
- W2022585532 cites W2134132890 @default.
- W2022585532 cites W2134254929 @default.
- W2022585532 cites W2135647797 @default.
- W2022585532 cites W2135703618 @default.
- W2022585532 cites W2136325680 @default.
- W2022585532 cites W2142738135 @default.
- W2022585532 cites W2145738273 @default.
- W2022585532 cites W2147303583 @default.
- W2022585532 cites W2156098329 @default.
- W2022585532 cites W2156206361 @default.
- W2022585532 cites W2158380859 @default.
- W2022585532 cites W2158550197 @default.
- W2022585532 cites W2159780533 @default.
- W2022585532 cites W2160381081 @default.
- W2022585532 cites W2161057248 @default.
- W2022585532 cites W2163487275 @default.
- W2022585532 cites W2164753589 @default.
- W2022585532 cites W2166962558 @default.
- W2022585532 cites W2171980652 @default.
- W2022585532 cites W2269289618 @default.
- W2022585532 cites W97158386 @default.
- W2022585532 doi "https://doi.org/10.1182/blood-2008-07-170787" @default.
- W2022585532 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18971423" @default.
- W2022585532 hasPublicationYear "2009" @default.
- W2022585532 type Work @default.
- W2022585532 sameAs 2022585532 @default.
- W2022585532 citedByCount "396" @default.
- W2022585532 countsByYear W20225855322012 @default.
- W2022585532 countsByYear W20225855322013 @default.
- W2022585532 countsByYear W20225855322014 @default.
- W2022585532 countsByYear W20225855322015 @default.
- W2022585532 countsByYear W20225855322016 @default.
- W2022585532 countsByYear W20225855322017 @default.
- W2022585532 countsByYear W20225855322018 @default.
- W2022585532 countsByYear W20225855322019 @default.
- W2022585532 countsByYear W20225855322020 @default.
- W2022585532 countsByYear W20225855322021 @default.
- W2022585532 countsByYear W20225855322022 @default.
- W2022585532 countsByYear W20225855322023 @default.