Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022602132> ?p ?o ?g. }
- W2022602132 endingPage "473" @default.
- W2022602132 startingPage "463" @default.
- W2022602132 abstract "Glutathione depletion has been described in tissues obtained from several chronic diseases. Increased free radical production by inflammatory cells occurs in inflammatory bowel disease. We hypothesized that this could induce depletion of gut antioxidants. In this study, we examined the potential relationship between chronic inflammation and colonic glutathione levels. Using a validated assay, glutathione levels were determined in the mucosal-submucosal layer and the muscularis externa layer in surgical colonic specimens from 26 patients with ulcerative colitis, 14 patients with Crohn's colitis, and 10 patients who underwent partial colectomy for non-obstructive neoplasia. Inflammation was graded histologically. Glutathione levels were decreased in the muscularis externa and in the mucosal-submucosal layers from both ulcerative colitis and Crohn's colitis (both p<0.05). There were parallel declines of glutathione levels in the muscularis externa layer compared to the mucosal-submucosal layer from individual colonic specimens. In ulcerative colitis, glutathione levels were reduced in histologically active disease compared to inactive disease (in the mucosal-submucosal layers: Mean±SEM were 214±68 nmol/g wet tissue and 808±30, respectively; in the muscularis externa layers: 333±97 and 890±340; both p<0.05). In Crohn's colitis, there were no significant differences between histologically active and inactive disease (in the mucosal-submucosal layers: 114±53 and 461±206; in the muscularis externa layers: 105±59 and 553±211; both p>0.05). This study provides evidence that chronic inflammatory disorders of the colon are associated with glutathione depletion. In ulcerative colitis, there was a relationship between the severity of inflammation and glutathione depletion. By contrast, this relationship was not significant in Crohn's colitis. The results suggest that there could be a primary defect in glutathione production in Crohn's colitis, or a difference in the relative levels of free radical production by inflammatory cells present in these two disorders of colonic inflammation." @default.
- W2022602132 created "2016-06-24" @default.
- W2022602132 creator A5003837295 @default.
- W2022602132 creator A5017202499 @default.
- W2022602132 creator A5033357339 @default.
- W2022602132 creator A5036015196 @default.
- W2022602132 creator A5049739840 @default.
- W2022602132 creator A5069245141 @default.
- W2022602132 creator A5079906405 @default.
- W2022602132 creator A5087808292 @default.
- W2022602132 date "1997-03-01" @default.
- W2022602132 modified "2023-09-26" @default.
- W2022602132 title "Glutathione levels in chronic inflammatory disorders of the human colon" @default.
- W2022602132 cites W1572936019 @default.
- W2022602132 cites W1602033104 @default.
- W2022602132 cites W1963571350 @default.
- W2022602132 cites W1967995886 @default.
- W2022602132 cites W1979562004 @default.
- W2022602132 cites W1980879049 @default.
- W2022602132 cites W1985687346 @default.
- W2022602132 cites W1996020833 @default.
- W2022602132 cites W2002150254 @default.
- W2022602132 cites W2016098250 @default.
- W2022602132 cites W2018196449 @default.
- W2022602132 cites W2026054193 @default.
- W2022602132 cites W2046921133 @default.
- W2022602132 cites W2048764296 @default.
- W2022602132 cites W2058748520 @default.
- W2022602132 cites W2059325107 @default.
- W2022602132 cites W2092305480 @default.
- W2022602132 cites W2095544553 @default.
- W2022602132 cites W2101757482 @default.
- W2022602132 cites W2127209006 @default.
- W2022602132 cites W2142697870 @default.
- W2022602132 cites W2153857454 @default.
- W2022602132 doi "https://doi.org/10.1016/s0271-5317(97)00007-9" @default.
- W2022602132 hasPublicationYear "1997" @default.
- W2022602132 type Work @default.
- W2022602132 sameAs 2022602132 @default.
- W2022602132 citedByCount "19" @default.
- W2022602132 countsByYear W20226021322013 @default.
- W2022602132 countsByYear W20226021322014 @default.
- W2022602132 countsByYear W20226021322015 @default.
- W2022602132 countsByYear W20226021322017 @default.
- W2022602132 countsByYear W20226021322018 @default.
- W2022602132 countsByYear W20226021322019 @default.
- W2022602132 countsByYear W20226021322020 @default.
- W2022602132 crossrefType "journal-article" @default.
- W2022602132 hasAuthorship W2022602132A5003837295 @default.
- W2022602132 hasAuthorship W2022602132A5017202499 @default.
- W2022602132 hasAuthorship W2022602132A5033357339 @default.
- W2022602132 hasAuthorship W2022602132A5036015196 @default.
- W2022602132 hasAuthorship W2022602132A5049739840 @default.
- W2022602132 hasAuthorship W2022602132A5069245141 @default.
- W2022602132 hasAuthorship W2022602132A5079906405 @default.
- W2022602132 hasAuthorship W2022602132A5087808292 @default.
- W2022602132 hasConcept C126322002 @default.
- W2022602132 hasConcept C142724271 @default.
- W2022602132 hasConcept C181199279 @default.
- W2022602132 hasConcept C2775862500 @default.
- W2022602132 hasConcept C2776914184 @default.
- W2022602132 hasConcept C2777960253 @default.
- W2022602132 hasConcept C2778260677 @default.
- W2022602132 hasConcept C2779134260 @default.
- W2022602132 hasConcept C2780479503 @default.
- W2022602132 hasConcept C538909803 @default.
- W2022602132 hasConcept C55493867 @default.
- W2022602132 hasConcept C71924100 @default.
- W2022602132 hasConcept C86803240 @default.
- W2022602132 hasConcept C90924648 @default.
- W2022602132 hasConceptScore W2022602132C126322002 @default.
- W2022602132 hasConceptScore W2022602132C142724271 @default.
- W2022602132 hasConceptScore W2022602132C181199279 @default.
- W2022602132 hasConceptScore W2022602132C2775862500 @default.
- W2022602132 hasConceptScore W2022602132C2776914184 @default.
- W2022602132 hasConceptScore W2022602132C2777960253 @default.
- W2022602132 hasConceptScore W2022602132C2778260677 @default.
- W2022602132 hasConceptScore W2022602132C2779134260 @default.
- W2022602132 hasConceptScore W2022602132C2780479503 @default.
- W2022602132 hasConceptScore W2022602132C538909803 @default.
- W2022602132 hasConceptScore W2022602132C55493867 @default.
- W2022602132 hasConceptScore W2022602132C71924100 @default.
- W2022602132 hasConceptScore W2022602132C86803240 @default.
- W2022602132 hasConceptScore W2022602132C90924648 @default.
- W2022602132 hasIssue "3" @default.
- W2022602132 hasLocation W20226021321 @default.
- W2022602132 hasOpenAccess W2022602132 @default.
- W2022602132 hasPrimaryLocation W20226021321 @default.
- W2022602132 hasRelatedWork W1596258860 @default.
- W2022602132 hasRelatedWork W1998231725 @default.
- W2022602132 hasRelatedWork W2105447106 @default.
- W2022602132 hasRelatedWork W2163484143 @default.
- W2022602132 hasRelatedWork W2750722062 @default.
- W2022602132 hasRelatedWork W3045491224 @default.
- W2022602132 hasRelatedWork W3129953011 @default.
- W2022602132 hasRelatedWork W3204746024 @default.
- W2022602132 hasRelatedWork W46359855 @default.
- W2022602132 hasRelatedWork W74726072 @default.