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- W2022602759 abstract "Abstract– Dopamine (DA) is degradated in part by MAO, an intraneuronal and glial enzyme localized at the outer mitochondrial membrane. DA is a good substrate for MAO-B and selegiline enhances DA-transmission and improves akinesia of Parkinson's disease (PD) by selective MAO-B blockade. Immunocytochemistry (ICC) and histochemistry (HC) demonstrate that neurons of substantia nigra (SN) lack MAO near totally (but see Moll et al 1988). Consequently, inhibition of MAO-B in this brain area occurs mainly in glial cells. Therefore an increase of DA in glia seems to be of long-lasting therapeutic benefit in PD. In addition, synthesis of hydrogen peroxide generated via MAO-B is blocked by selegiline. By this toxicity by endogenous free radicals is diminished. Furthermore, exogenous neurotoxicity by MAO-B substrates can be prevented by inhibition of MAO-B, while such MAO-A substrates are metabolized at the level of the MAO-A containing endothelium of capillaries. As conclusion, selegiline is a safe inhibitor of MAO-B that reduces neurotoxicity possibly triggering PD. Brain area MAO-A MAO-B ICC HC ICC HC DRN • — +++ +++ LC +++ +++ — — SN —(+10%)' — — — Astroglia +++ + +++ +++ — without reaction or staining + mild reaction; +++ intensive reaction or staining; DRN dorsal raphe nucleus; LC locus coeruleus; 'Moll et al. 1988" @default.
- W2022602759 created "2016-06-24" @default.
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- W2022602759 date "1989-11-01" @default.
- W2022602759 modified "2023-09-23" @default.
- W2022602759 title "Neurochemical perspectives to the function of monoamine oxidase" @default.
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- W2022602759 doi "https://doi.org/10.1111/j.1600-0404.1989.tb01781.x" @default.
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