Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022602971> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2022602971 abstract "Deep brain stimulation of the subthalamic nucleus (DBS-STN) is thought to continuously alter the activity of STN neurons in Parkinson's disease (PD). A chronic decrease in the levodopa dose with continuous STN stimulation may induce plastic neuronal changes.The objective of this work was to study urinary excretion of catecholamines in patients with PD before and after DBS-STN.Twenty-three patients were submitted to DBS-STN, and evaluated before and after surgery with respect to catecholamines and metabolites in 24-h urine measured by high-performance liquid chromatography with electrochemical detection.Of the 23 patients evaluated, a significant decrease of about 60% in the urinary excretion of L-3,4-dihydroxyphenylalanine (L-DOPA; in nmol/mg creatinine/24 h) was observed 1 week after DBS-STN. Moreover, in 17 patients with a follow-up of 8 weeks after surgery, there was a further 50% decrease in urinary L-DOPA levels, dropping to about 75% of the values before surgery. There was also a significant decrease in dopamine (DA) and 3,4-dihydroxyphenylacetic acid (DOPAC) levels 1 week after DBS-STN that was no longer present 8 weeks after. A significant increase in the DA/l-DOPA ratio was observed 1 week after surgery, with a further increase 8 weeks after surgery.After DBS-STN, the DA/l-DOPA ratio, an indirect measure of DA synthesis, increased. These results show that DBS-STN may improve the efficacy of oral levodopa." @default.
- W2022602971 created "2016-06-24" @default.
- W2022602971 creator A5009528074 @default.
- W2022602971 creator A5020895331 @default.
- W2022602971 creator A5026172339 @default.
- W2022602971 creator A5031066597 @default.
- W2022602971 creator A5047378993 @default.
- W2022602971 creator A5062264742 @default.
- W2022602971 creator A5068523585 @default.
- W2022602971 date "2013-05-17" @default.
- W2022602971 modified "2023-09-26" @default.
- W2022602971 title "Urinary profile of catecholamines and metabolites in Parkinson patients with deep brain stimulation" @default.
- W2022602971 cites W140137023 @default.
- W2022602971 cites W1544052774 @default.
- W2022602971 cites W1996477091 @default.
- W2022602971 cites W2020078576 @default.
- W2022602971 cites W2021986312 @default.
- W2022602971 cites W2040897011 @default.
- W2022602971 cites W2042377848 @default.
- W2022602971 cites W2053547178 @default.
- W2022602971 cites W2067590452 @default.
- W2022602971 cites W2104200794 @default.
- W2022602971 cites W2128252931 @default.
- W2022602971 cites W2141410612 @default.
- W2022602971 cites W2165152810 @default.
- W2022602971 cites W2168456591 @default.
- W2022602971 doi "https://doi.org/10.1111/ene.12161" @default.
- W2022602971 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23679894" @default.
- W2022602971 hasPublicationYear "2013" @default.
- W2022602971 type Work @default.
- W2022602971 sameAs 2022602971 @default.
- W2022602971 citedByCount "6" @default.
- W2022602971 countsByYear W20226029712015 @default.
- W2022602971 countsByYear W20226029712016 @default.
- W2022602971 countsByYear W20226029712018 @default.
- W2022602971 countsByYear W20226029712019 @default.
- W2022602971 crossrefType "journal-article" @default.
- W2022602971 hasAuthorship W2022602971A5009528074 @default.
- W2022602971 hasAuthorship W2022602971A5020895331 @default.
- W2022602971 hasAuthorship W2022602971A5026172339 @default.
- W2022602971 hasAuthorship W2022602971A5031066597 @default.
- W2022602971 hasAuthorship W2022602971A5047378993 @default.
- W2022602971 hasAuthorship W2022602971A5062264742 @default.
- W2022602971 hasAuthorship W2022602971A5068523585 @default.
- W2022602971 hasConcept C126322002 @default.
- W2022602971 hasConcept C126894567 @default.
- W2022602971 hasConcept C24998067 @default.
- W2022602971 hasConcept C2777319143 @default.
- W2022602971 hasConcept C2778542668 @default.
- W2022602971 hasConcept C2779134260 @default.
- W2022602971 hasConcept C2779734285 @default.
- W2022602971 hasConcept C2780304432 @default.
- W2022602971 hasConcept C42219234 @default.
- W2022602971 hasConcept C513476851 @default.
- W2022602971 hasConcept C71924100 @default.
- W2022602971 hasConcept C77411442 @default.
- W2022602971 hasConceptScore W2022602971C126322002 @default.
- W2022602971 hasConceptScore W2022602971C126894567 @default.
- W2022602971 hasConceptScore W2022602971C24998067 @default.
- W2022602971 hasConceptScore W2022602971C2777319143 @default.
- W2022602971 hasConceptScore W2022602971C2778542668 @default.
- W2022602971 hasConceptScore W2022602971C2779134260 @default.
- W2022602971 hasConceptScore W2022602971C2779734285 @default.
- W2022602971 hasConceptScore W2022602971C2780304432 @default.
- W2022602971 hasConceptScore W2022602971C42219234 @default.
- W2022602971 hasConceptScore W2022602971C513476851 @default.
- W2022602971 hasConceptScore W2022602971C71924100 @default.
- W2022602971 hasConceptScore W2022602971C77411442 @default.
- W2022602971 hasLocation W20226029711 @default.
- W2022602971 hasLocation W20226029712 @default.
- W2022602971 hasOpenAccess W2022602971 @default.
- W2022602971 hasPrimaryLocation W20226029711 @default.
- W2022602971 hasRelatedWork W1968293710 @default.
- W2022602971 hasRelatedWork W1992444747 @default.
- W2022602971 hasRelatedWork W2025652420 @default.
- W2022602971 hasRelatedWork W2044028780 @default.
- W2022602971 hasRelatedWork W2052529053 @default.
- W2022602971 hasRelatedWork W2075669169 @default.
- W2022602971 hasRelatedWork W2076264484 @default.
- W2022602971 hasRelatedWork W2080264897 @default.
- W2022602971 hasRelatedWork W2087420400 @default.
- W2022602971 hasRelatedWork W2087703280 @default.
- W2022602971 hasRelatedWork W2089124818 @default.
- W2022602971 hasRelatedWork W2097967900 @default.
- W2022602971 hasRelatedWork W2108883253 @default.
- W2022602971 hasRelatedWork W2120873333 @default.
- W2022602971 hasRelatedWork W2402642205 @default.
- W2022602971 hasRelatedWork W2418713095 @default.
- W2022602971 hasRelatedWork W2592130454 @default.
- W2022602971 hasRelatedWork W3016469266 @default.
- W2022602971 hasRelatedWork W3092351947 @default.
- W2022602971 hasRelatedWork W1576238537 @default.
- W2022602971 isParatext "false" @default.
- W2022602971 isRetracted "false" @default.
- W2022602971 magId "2022602971" @default.
- W2022602971 workType "article" @default.