FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022603305> ?p ?o ?g. }

• W2022603305 endingPage "e1000864" @default.
• W2022603305 startingPage "e1000864" @default.
• W2022603305 abstract "The capacity of infected cells to undergo apoptosis upon insult with a pathogen is an ancient innate immune defense mechanism. Consequently, the ability of persisting, intracellular pathogens such as the human pathogen Mycobacterium tuberculosis (Mtb) to inhibit infection-induced apoptosis of macrophages is important for virulence. The nuoG gene of Mtb, which encodes the NuoG subunit of the type I NADH dehydrogenase, NDH-1, is important in Mtb-mediated inhibition of host macrophage apoptosis, but the molecular mechanism of this host pathogen interaction remains elusive. Here we show that the apoptogenic phenotype of MtbDeltanuoG was significantly reduced in human macrophages treated with caspase-3 and -8 inhibitors, TNF-alpha-neutralizing antibodies, and also after infection of murine TNF(-/-) macrophages. Interestingly, incubation of macrophages with inhibitors of reactive oxygen species (ROS) reduced not only the apoptosis induced by the nuoG mutant, but also its capacity to increase macrophage TNF-alpha secretion. The MtbDeltanuoG phagosomes showed increased ROS levels compared to Mtb phagosomes in primary murine and human alveolar macrophages. The increase in MtbDeltanuoG induced ROS and apoptosis was abolished in NOX-2 deficient (gp91(-/-)) macrophages. These results suggest that Mtb, via a NuoG-dependent mechanism, can neutralize NOX2-derived ROS in order to inhibit TNF-alpha-mediated host cell apoptosis. Consistently, an Mtb mutant deficient in secreted catalase induced increases in phagosomal ROS and host cell apoptosis, both of which were dependent upon macrophage NOX-2 activity. In conclusion, these results serendipitously reveal a novel connection between NOX2 activity, phagosomal ROS, and TNF-alpha signaling during infection-induced apoptosis in macrophages. Furthermore, our study reveals a novel function of NOX2 activity in innate immunity beyond the initial respiratory burst, which is the sensing of persistent intracellular pathogens and subsequent induction of host cell apoptosis as a second line of defense." @default.
• W2022603305 created "2016-06-24" @default.
• W2022603305 creator A5006174873 @default.
• W2022603305 creator A5043850885 @default.
• W2022603305 creator A5083029425 @default.
• W2022603305 creator A5084217131 @default.
• W2022603305 date "2010-04-22" @default.
• W2022603305 modified "2023-10-15" @default.
• W2022603305 title "The Type I NADH Dehydrogenase of Mycobacterium tuberculosis Counters Phagosomal NOX2 Activity to Inhibit TNF-α-Mediated Host Cell Apoptosis" @default.
• W2022603305 cites W1539623201 @default.
• W2022603305 cites W1817088045 @default.
• W2022603305 cites W1926098097 @default.
• W2022603305 cites W1938998220 @default.
• W2022603305 cites W1974309182 @default.
• W2022603305 cites W1976575734 @default.
• W2022603305 cites W1977225705 @default.
• W2022603305 cites W1983476428 @default.
• W2022603305 cites W1985293833 @default.
• W2022603305 cites W1985779248 @default.
• W2022603305 cites W1987405020 @default.
• W2022603305 cites W2006252982 @default.
• W2022603305 cites W2008815515 @default.
• W2022603305 cites W2016865932 @default.
• W2022603305 cites W2033586457 @default.
• W2022603305 cites W2037060196 @default.
• W2022603305 cites W2048597976 @default.
• W2022603305 cites W2056045766 @default.
• W2022603305 cites W2058051642 @default.
• W2022603305 cites W2062409682 @default.
• W2022603305 cites W2065791817 @default.
• W2022603305 cites W2066515050 @default.
• W2022603305 cites W2066719237 @default.
• W2022603305 cites W2068981042 @default.
• W2022603305 cites W2080850609 @default.
• W2022603305 cites W2081287274 @default.
• W2022603305 cites W2084457694 @default.
• W2022603305 cites W2085128107 @default.
• W2022603305 cites W2085371907 @default.
• W2022603305 cites W2085568061 @default.
• W2022603305 cites W2085926680 @default.
• W2022603305 cites W2090709734 @default.
• W2022603305 cites W2093631337 @default.
• W2022603305 cites W2094389347 @default.
• W2022603305 cites W2094496555 @default.
• W2022603305 cites W2103512536 @default.
• W2022603305 cites W2105699218 @default.
• W2022603305 cites W2114111268 @default.
• W2022603305 cites W2124765964 @default.
• W2022603305 cites W2124930223 @default.
• W2022603305 cites W2128684280 @default.
• W2022603305 cites W2138989146 @default.
• W2022603305 cites W2139012536 @default.
• W2022603305 cites W2142569707 @default.
• W2022603305 cites W2144300164 @default.
• W2022603305 cites W2156442967 @default.
• W2022603305 cites W2162815684 @default.
• W2022603305 cites W2165242934 @default.
• W2022603305 cites W2165494441 @default.
• W2022603305 cites W2165536326 @default.
• W2022603305 doi "https://doi.org/10.1371/journal.ppat.1000864" @default.
• W2022603305 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2858756" @default.
• W2022603305 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20421951" @default.
• W2022603305 hasPublicationYear "2010" @default.
• W2022603305 type Work @default.
• W2022603305 sameAs 2022603305 @default.
• W2022603305 citedByCount "154" @default.
• W2022603305 countsByYear W20226033052012 @default.
• W2022603305 countsByYear W20226033052013 @default.
• W2022603305 countsByYear W20226033052014 @default.
• W2022603305 countsByYear W20226033052015 @default.
• W2022603305 countsByYear W20226033052016 @default.
• W2022603305 countsByYear W20226033052017 @default.
• W2022603305 countsByYear W20226033052018 @default.
• W2022603305 countsByYear W20226033052019 @default.
• W2022603305 countsByYear W20226033052020 @default.
• W2022603305 countsByYear W20226033052021 @default.
• W2022603305 countsByYear W20226033052022 @default.
• W2022603305 countsByYear W20226033052023 @default.
• W2022603305 crossrefType "journal-article" @default.
• W2022603305 hasAuthorship W2022603305A5006174873 @default.
• W2022603305 hasAuthorship W2022603305A5043850885 @default.
• W2022603305 hasAuthorship W2022603305A5083029425 @default.
• W2022603305 hasAuthorship W2022603305A5084217131 @default.
• W2022603305 hasBestOaLocation W20226033051 @default.
• W2022603305 hasConcept C161478664 @default.
• W2022603305 hasConcept C17991360 @default.
• W2022603305 hasConcept C190283241 @default.
• W2022603305 hasConcept C202751555 @default.
• W2022603305 hasConcept C203014093 @default.
• W2022603305 hasConcept C2779244956 @default.
• W2022603305 hasConcept C48349386 @default.
• W2022603305 hasConcept C55493867 @default.
• W2022603305 hasConcept C79879829 @default.
• W2022603305 hasConcept C86803240 @default.
• W2022603305 hasConcept C89423630 @default.
• W2022603305 hasConcept C95444343 @default.
• W2022603305 hasConceptScore W2022603305C161478664 @default.
• W2022603305 hasConceptScore W2022603305C17991360 @default.

• next