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• W2022603313 abstract "To understand the pathogenesis of scrub typhus, we examined chemokine and cytokine production in susceptible (C3H/HeN) and resistant (BALB/c) mice after infection with O. tsutsugamushi Gilliam. C3H/HeN mice produced high levels of chemokines macrophage inflammatory proteins 1α (MIP-1α), MIP-2, monocyte chemoattractant protein 1 (MCP-1), and cytokines gamma-interferon (IFN-γ), interleukin-12 (IL-12), IL-10, and tumor necrosis factor alpha (TNF-α) in response to O. tsutsugamushi infection, compared to BALB/c mice. Chemokine profiles in infected mice correlated well with the kinetics of inflammatory cell infiltration. Hyperproduction of chemokines and cytokines was observed in another susceptible-infection model (BALB/c-Karp). These results suggest that hyperproduction of chemokines and cytokines are associated with susceptibility during O. tsutsugamushi infection." @default.
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• W2022603313 date "2005-06-01" @default.
• W2022603313 modified "2023-10-16" @default.
• W2022603313 title "Chemokine and Cytokine Production in Susceptible C3H/HeN Mice and Resistant BALB/c Mice during<i>Orientia tsutsugamushi</i>Infection" @default.
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• W2022603313 doi "https://doi.org/10.1111/j.1348-0421.2005.tb03761.x" @default.
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