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- W2022603982 abstract "Individuals heterozygous for the Greek (Aγ) variant of hereditary persistence of fetal haemoglobin (HPFH) synthesize Hb F whose γ-globin chains are predominantly of the Aγ type. DNA obtained from Greek HPFH heterozygotes was used to test for abnormalities in the organization of non α-globin genes. In addition, γ- and β-globin expression was studied in BFUe cultures. Restriction endonuclease mapping showed that the γGγ, δ and β genes in cis to the Greek HPFH determinant are intact. Overproduction of γ-globin chains synthesis was observed in the BFUe cultures. A significant portion of the γ chain synthesis was of the Gγ type, suggesting that the Gγ genes cis and trans to the HPFH chromosome are active in culture." @default.
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- W2022603982 date "1982-03-01" @default.
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- W2022603982 title "Greek (Aγ) variant of hereditary persistence of fetal haemoglobin: globin gene organization and studies of expression of fetal haemoglobins in clonal erythroid cultures" @default.
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- W2022603982 doi "https://doi.org/10.1111/j.1365-2141.1982.tb01934.x" @default.
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