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• W2022604348 abstract "The quantitative role of the phosphoenolpyruvate:glucose phosphotransferase system (glucose phosphotransferase system) in glucose uptake and metabolism, and phosphotransferase-system-mediated regulation of glycerol uptake, was studied in vivo in Salmonella typhimurium. Expression plasmids were constructed which contained the genes encoding enzyme I (ptsI), HPr (ptsH), IIAGlc (crr), and IICBGlc (ptsG) of the glucose phosphotransferase system behind inducible promoters. These plasmids allowed the controlled expression of each of the glucose phosphotransferase system proteins from about 30 % to about 300% of its wild-type level. When enzyme I, HPr or IIAGlc were modulated between 30% and 300% of their wild-type value, hardly any effects on the growth rate on glucose, the glucose oxidation rate, the rate of methyl α-d-glucopyranoside (a glucose analog) uptake or the phosphotransferase-system-mediated inhibition of glycerol uptake by methyl α-d-glucopyranoside were observed. Employing the method of metabolic control analysis, it was shown that the enzyme flux control coefficients of these phosphotransferase system components on the different measured processes were close to zero. The enzyme flux control coefficient of IICBGlc on growth on glucose or glucose oxidation was also close to zero. In contrast, the enzyme flux control coefficient of IICBGlc on the flux through the glucose phosphotransferase system (transport and phosphorylation) was 0.72. The experimentally determined enzyme flux control coefficients allowed us to calculate the flux control coefficients of the phosphoenolpyruvate/pyruvate and methyl α-d-glucopyranoside/methyl α-d-glucopyranoside 6-phosphate couples and the process control coefficients of the phosphotransfer reactions of the glucose phosphotransferase system. We discuss the implications of these values and the possible control points in the glucose phosphotransferase system." @default.
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• W2022604348 date "1995-05-01" @default.
• W2022604348 modified "2023-10-13" @default.
• W2022604348 title "Control of Glucose Metabolism by the Enzymes of the Glucose Phosphotransferase System in Salmonella typhimurium" @default.
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• W2022604348 doi "https://doi.org/10.1111/j.1432-1033.1995.0170i.x" @default.
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