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• W2022604415 startingPage "909" @default.
• W2022604415 abstract "It is well established that brain metabolism is higher during wake and rapid eye movement (REM) sleep than in nonrapid eye movement (NREM) sleep. Most of the brain's energy is used to maintain neuronal firing and glutamatergic transmission. Recent evidence shows that cortical firing rates, extracellular glutamate levels, and markers of excitatory synaptic strength increase with time spent awake and decline throughout NREM sleep. These data imply that the metabolic cost of each behavioral state is not fixed but may reflect sleep-wake history, a possibility that is investigated in the current report.Chronic (4d) electroencephalographic (EEG) recordings in the rat cerebral cortex were coupled with fixed-potential amperometry to monitor the extracellular concentration of oxygen ([oxy]) and lactate ([lac]) on a second-by-second basis across the spontaneous sleep-wake cycle and in response to sleep deprivation.Basic sleep research laboratory.Wistar Kyoto (WKY) adult male rats.N/A.Within 30-60 sec [lac] and [oxy] progressively increased during wake and REM sleep and declined during NREM sleep (n = 10 rats/metabolite), but with several differences. [Oxy], but not [lac], increased more during wake with high motor activity and/or elevated EEG high-frequency power. Meanwhile, only the NREM decline of [lac] reflected sleep pressure as measured by slow-wave activity, mirroring previous results for cortical glutamate.The observed state-dependent changes in cortical [lac] and [oxy] are consistent with higher brain metabolism during waking and REM sleep in comparison with NREM sleep. Moreover, these data suggest that glycolytic activity, most likely through its link with glutamatergic transmission, reflects sleep homeostasis." @default.
• W2022604415 created "2016-06-24" @default.
• W2022604415 creator A5001381023 @default.
• W2022604415 creator A5024483689 @default.
• W2022604415 creator A5056505967 @default.
• W2022604415 date "2012-07-01" @default.
• W2022604415 modified "2023-10-12" @default.
• W2022604415 title "Extracellular Levels of Lactate, but Not Oxygen, Reflect Sleep Homeostasis in the Rat Cerebral Cortex" @default.
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• W2022604415 doi "https://doi.org/10.5665/sleep.1950" @default.
• W2022604415 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3369226" @default.
• W2022604415 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22754037" @default.
• W2022604415 hasPublicationYear "2012" @default.
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