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- W2022604528 abstract "Ischemic preconditioning is emerging as an innovative and novel cytoprotective strategy to counter ischemic vascular disease. At the root of the preconditioning response is the upregulation of endogenous defense systems to achieve ischemic tolerance. Identifying suitable biomarkers to show that a preconditioning response has been induced remains a translational research priority. Preconditioning leads to a widespread genomic and proteonomic response with important effects on hemostatic, endothelial, and inflammatory systems. The present article summarizes the relevant preclinical studies defining the mechanisms of preconditioning, reviews how the human preconditioning response has been investigated, and which of these bioresponses could serve as a suitable biomarker. Human preconditioning studies have investigated the effects of preconditioning on coagulation, endothelial factors, and inflammatory mediators as well as on genetic expression and tissue blood flow imaging. A biomarker for preconditioning would significantly contribute to define the optimal preconditioning stimulus and the extent to which such a response can be elicited in humans and greatly aid in dose selection in the design of phase II trials. Given the manifold biologic effects of preconditioning a panel of multiple serum biomarkers or genomic assessments of upstream regulators may most accurately reflect the full spectrum of a preconditioning response." @default.
- W2022604528 created "2016-06-24" @default.
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- W2022604528 creator A5028129787 @default.
- W2022604528 creator A5032836389 @default.
- W2022604528 date "2014-03-19" @default.
- W2022604528 modified "2023-10-06" @default.
- W2022604528 title "Biomarkers for Ischemic Preconditioning: Finding the Responders" @default.
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- W2022604528 doi "https://doi.org/10.1038/jcbfm.2014.42" @default.
- W2022604528 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4050240" @default.
- W2022604528 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24643082" @default.
- W2022604528 hasPublicationYear "2014" @default.
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