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- W2022605561 startingPage "647" @default.
- W2022605561 abstract "Over the last few decades, concepts regarding the presence of hormonal and molecular responses to stress during the first postnatal weeks in the rat and the role of the neuropeptide corticotropin releasing hormone (CRH) in these processes, have been evolving. CRH has been shown to contribute critically to molecular and neuroendocrine responses to stress during development. In turn the expression of this neuropeptide in both hypothalamus and amygdala is differentially modulated by single and recurrent stress, and is determined also by the type of stress (eg, psychological or physiological). A likely transcriptional regulatory factor for modulating CRH gene expression, the cAMP responsive element binding protein CREB, is phosphorylated (activated) in the developing hypothalamus within seconds of stress onset, preceding the transcription of the CRH gene and initiating the activation of stress-induced cellular and neuroendocrine cascades. Finally, early life stress may permanently modify the hypothalamic pituitary adrenal axis and the response to further stressful stimuli, and recent data suggest that CRH may play an integral role in the mechanisms of these long-term changes." @default.
- W2022605561 created "2016-06-24" @default.
- W2022605561 creator A5021541263 @default.
- W2022605561 creator A5051246803 @default.
- W2022605561 creator A5051388310 @default.
- W2022605561 creator A5058877320 @default.
- W2022605561 date "2001-10-23" @default.
- W2022605561 modified "2023-10-18" @default.
- W2022605561 title "Neurobiology of the stress response early in life: evolution of a concept and the role of corticotropin releasing hormone" @default.
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