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- W2022605812 abstract "Abstract Methylmercury chloride (MeHg) was administered to five monkeys. Electrooculography (EOG) was used as an objective measure of vestibular and oculomotor functions. Monkeys with acute and subacute exposures to MeHg exhibited spontaneous nystagmus and positional nystagmus of the apogeotropic type which were the earliest indications of dysfunction prior to the onset of clinical signs and symptoms. In these monkeys the slow-phase velocity of optokinetic nystagmus (OKN) waxed and waned with every test. At velocities of optokinetic stimuli greater than 50°/s, the slow-phase velocity of OKN fluctuated during every test and lagged behind the velocity of the optokinetic stimuli. The second and third phases of optokinetic after-nystagmus appeared at an early stage of the experiment, and were accompanied by the second and third phases of caloric nystagmus. Visual suppression (VS) of caloric nystagmus was normal for MeHg dosages up to 10 mg/kg. Larger dosages resulted in a loss of VS which was observed several days before severe neurological signs and symptoms appeared, and OKN was impaired. Monkeys which were administered minimum MeHg dosage equal to one-tenth of those in monkeys with acute and subacute exposures did not show any neurological or histological changes. The only significant positive signs were spontaneous nystagmus and positional nystagmus. Hence, the EOG is very sensitive to functional disturbances and can be utilized to detect dysfunction in MeHg intoxication." @default.
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- W2022605812 date "1981-04-01" @default.
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- W2022605812 title "Electrooculographic evaluation of methylmercury intoxication in monkeys" @default.
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- W2022605812 doi "https://doi.org/10.1016/0014-4886(81)90126-6" @default.
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