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• W2022606144 abstract "Abstract Background The early diagnosis and treatment of heart failure in β‐thalassaemic patients is related to survival. Iron alone or in combination with other factors causes diastolic dysfunction, which usually precedes systolic dysfunction. NT‐proBNP is a sensitive biomarker of ventricular dysfunction. Aim To evaluate NT‐proBNP in non heart failure β‐thalassaemic patients. Methods Fifty‐two β‐thalassaemia major patients (mean age: 27.2±12.5 years) with normal LV systolic function, underwent NT‐proBNP measurement and a thorough Doppler‐echocardiographic and pulsed tissue‐Doppler study, 4 days following blood transfusion. Fifty‐two age matched healthy controls were also studied. Results NT‐proBNP and E / E ′ ratio were increased in thalassaemic patients compared with controls [(469±171 vs 262±51 pmol/l, p <0.001) and (10.8±4.0 vs 6.6±1.1, p <0.001)] and were well correlated ( r : 0.54, p <0.01). Although NT‐proBNP levels were increased in patients with higher E / E ′ ratios ( E / E ′ <8: 354±119, 8–15: 516±177, >15: 565±114 pmol/l, ANOVA p : 0.002) this increase only became statistically significant in the 3rd decade of life, while E / E ′ ratio increased in the 4th decade. Conclusion NT‐proBNP increases in β‐thalassaemia major patients and is related to age and LV diastolic dysfunction. NT‐proBNP appears to be an early biomarker of LV diastolic dysfunction, compared with the conventional Echo‐Doppler indexes." @default.
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• W2022606144 date "2007-04-15" @default.
• W2022606144 modified "2023-10-17" @default.
• W2022606144 title "NT-proBNP levels and diastolic dysfunction in β-Thalassaemia major patients" @default.
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• W2022606144 doi "https://doi.org/10.1016/j.ejheart.2006.11.004" @default.
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