FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022606180> ?p ?o ?g. }

• W2022606180 endingPage "379" @default.
• W2022606180 startingPage "373" @default.
• W2022606180 abstract "We have constructed phospholipid vesicles with hemostatic activity as a platelet substitute. The vesicles were conjugated with a dodecapeptide (HHLGGAKQAGDV, H12), which is a fibrinogen γ-chain carboxy-terminal sequence (γ400–411). We have recently exploited these vesicles as a potential drug delivery system by encapsulation of adenosine 5'-diphosphate (ADP) (H12-(ADP)-vesicles). Here we explore the relationship between the ADP release from H12-(ADP)-vesicles with different membrane properties and their hemostatic effects. In total, we prepared five kinds of H12-(ADP)-vesicles with different lamellarities and membrane flexibilities. By radioisotope-labeling, we directly show that H12-(ADP)-vesicles were capable of augmenting platelet aggregation by releasing ADP in an aggregation-dependent manner. The amount of ADP released from the vesicles was dependent on their membrane properties. Specifically, the amount of ADP released increased with decreasing lamellarity and tended to increase with increasing membrane flexibility. Our in vivo results clearly demonstrated that H12-(ADP)-vesicles with the ability to release ADP exert considerable hemostatic action in terms of correcting prolonged bleeding time in a busulphan-induced thrombocytopenic rat model. We propose a recipe to control the hemostatic abilities of H12-(ADP)-vesicles by modulating ADP release based on membrane properties. We believe that this concept will be invaluable to the development of platelet substitutes and other drug carriers." @default.
• W2022606180 created "2016-06-24" @default.
• W2022606180 creator A5033854647 @default.
• W2022606180 creator A5037131620 @default.
• W2022606180 creator A5058909601 @default.
• W2022606180 creator A5063584467 @default.
• W2022606180 creator A5074835045 @default.
• W2022606180 creator A5076466436 @default.
• W2022606180 creator A5086525882 @default.
• W2022606180 date "2010-12-01" @default.
• W2022606180 modified "2023-10-15" @default.
• W2022606180 title "Release abilities of adenosine diphosphate from phospholipid vesicles with different membrane properties and their hemostatic effects as a platelet substitute" @default.
• W2022606180 cites W1480698319 @default.
• W2022606180 cites W1505283703 @default.
• W2022606180 cites W1533499340 @default.
• W2022606180 cites W1586686759 @default.
• W2022606180 cites W1972845382 @default.
• W2022606180 cites W1976366973 @default.
• W2022606180 cites W1981131409 @default.
• W2022606180 cites W1985336289 @default.
• W2022606180 cites W1998621525 @default.
• W2022606180 cites W2003546548 @default.
• W2022606180 cites W2018334262 @default.
• W2022606180 cites W2022948419 @default.
• W2022606180 cites W2041788732 @default.
• W2022606180 cites W2049863803 @default.
• W2022606180 cites W2051061301 @default.
• W2022606180 cites W2055870792 @default.
• W2022606180 cites W2066316096 @default.
• W2022606180 cites W2067836657 @default.
• W2022606180 cites W2073798993 @default.
• W2022606180 cites W2080374463 @default.
• W2022606180 cites W2085508149 @default.
• W2022606180 cites W2087870051 @default.
• W2022606180 cites W2090406006 @default.
• W2022606180 cites W2095009037 @default.
• W2022606180 cites W2098438673 @default.
• W2022606180 cites W2115153477 @default.
• W2022606180 cites W2127336590 @default.
• W2022606180 cites W2343674894 @default.
• W2022606180 cites W4211141663 @default.
• W2022606180 doi "https://doi.org/10.1016/j.jconrel.2010.09.013" @default.
• W2022606180 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20875473" @default.
• W2022606180 hasPublicationYear "2010" @default.
• W2022606180 type Work @default.
• W2022606180 sameAs 2022606180 @default.
• W2022606180 citedByCount "27" @default.
• W2022606180 countsByYear W20226061802012 @default.
• W2022606180 countsByYear W20226061802013 @default.
• W2022606180 countsByYear W20226061802014 @default.
• W2022606180 countsByYear W20226061802015 @default.
• W2022606180 countsByYear W20226061802017 @default.
• W2022606180 countsByYear W20226061802019 @default.
• W2022606180 countsByYear W20226061802020 @default.
• W2022606180 countsByYear W20226061802021 @default.
• W2022606180 countsByYear W20226061802022 @default.
• W2022606180 countsByYear W20226061802023 @default.
• W2022606180 crossrefType "journal-article" @default.
• W2022606180 hasAuthorship W2022606180A5033854647 @default.
• W2022606180 hasAuthorship W2022606180A5037131620 @default.
• W2022606180 hasAuthorship W2022606180A5058909601 @default.
• W2022606180 hasAuthorship W2022606180A5063584467 @default.
• W2022606180 hasAuthorship W2022606180A5074835045 @default.
• W2022606180 hasAuthorship W2022606180A5076466436 @default.
• W2022606180 hasAuthorship W2022606180A5086525882 @default.
• W2022606180 hasConcept C12554922 @default.
• W2022606180 hasConcept C130316041 @default.
• W2022606180 hasConcept C185154212 @default.
• W2022606180 hasConcept C185592680 @default.
• W2022606180 hasConcept C203014093 @default.
• W2022606180 hasConcept C2777399203 @default.
• W2022606180 hasConcept C2778918659 @default.
• W2022606180 hasConcept C2993802102 @default.
• W2022606180 hasConcept C41625074 @default.
• W2022606180 hasConcept C55493867 @default.
• W2022606180 hasConcept C86803240 @default.
• W2022606180 hasConcept C89560881 @default.
• W2022606180 hasConceptScore W2022606180C12554922 @default.
• W2022606180 hasConceptScore W2022606180C130316041 @default.
• W2022606180 hasConceptScore W2022606180C185154212 @default.
• W2022606180 hasConceptScore W2022606180C185592680 @default.
• W2022606180 hasConceptScore W2022606180C203014093 @default.
• W2022606180 hasConceptScore W2022606180C2777399203 @default.
• W2022606180 hasConceptScore W2022606180C2778918659 @default.
• W2022606180 hasConceptScore W2022606180C2993802102 @default.
• W2022606180 hasConceptScore W2022606180C41625074 @default.
• W2022606180 hasConceptScore W2022606180C55493867 @default.
• W2022606180 hasConceptScore W2022606180C86803240 @default.
• W2022606180 hasConceptScore W2022606180C89560881 @default.
• W2022606180 hasIssue "3" @default.
• W2022606180 hasLocation W20226061801 @default.
• W2022606180 hasLocation W20226061802 @default.
• W2022606180 hasOpenAccess W2022606180 @default.
• W2022606180 hasPrimaryLocation W20226061801 @default.
• W2022606180 hasRelatedWork W1998683556 @default.
• W2022606180 hasRelatedWork W2003731969 @default.
• W2022606180 hasRelatedWork W2009157011 @default.
• W2022606180 hasRelatedWork W2009857196 @default.

• next