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- W2022607436 abstract "To determine the safety and efficacy of glycopyrrolate in the treatment of developmentally disabled children with sialorrhea.Placebo-controlled, double-blind, crossover dose-ranging study.Outpatient facilities in 2 pediatric hospitals.Thirty-nine children with both developmental disabilities and excessive and bothersome sialorrhea.Parent and investigator evaluation of change in sialorrhea and adverse effects.Glycopyrrolate in doses of 0.10 mg/kg per dose is effective at controlling sialorrhea. Even at low doses, 20% of children may exhibit adverse effects severe enough to require discontinuation.Glycopyrrolate is effective in the control of excessive sialorrhea in children with developmental disabilities. Approximately 20% of children given glycopyrrolate may experience substantial adverse effects, enough to require discontinuation of medication. Arch Pediatr Adolesc Med. 2000;154:1214-1218." @default.
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- W2022607436 date "2000-12-01" @default.
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- W2022607436 title "Treatment of Sialorrhea With Glycopyrrolate" @default.
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- W2022607436 doi "https://doi.org/10.1001/archpedi.154.12.1214" @default.
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