Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022609984> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2022609984 endingPage "165" @default.
- W2022609984 startingPage "162" @default.
- W2022609984 abstract "Basic fibroblast growth factor (bFGF) is a potent mitogen for various cell types. We report here the first study of the effects of bFGF on a digestive tract-derived cell line. The effect of bFGF on the proliferation of AR4–2J cells, tumor cells of acinar pancreatic origin, was investigated together with modulation of ornithine decarboxylase (ODC) activity, an intracellular event involved in cell proliferation. bFGF caused a concentration-dependent stimulation of AR4–2J cell growth, with a half maximal effect (EC50) at 22 ± 2 pM. ODC activity, assayed by the CO2-trapping method, was also increased by bFGF in a dose-dependent manner, reaching half-maximal stimulation at 20 pM. We conclude that bFGF is a very potent growth promoting factor for cells of pancreatic origin, already effective at picomolar concentrations. The parallelism between the growth assay and the ODC activity assay implicates the involvement of ODC activity in the pathway of the mitogenic effect of bFGF. The stimulation of ODC activity therefore seems to be a reliable early marker for cell proliferation in this model." @default.
- W2022609984 created "2016-06-24" @default.
- W2022609984 creator A5006481318 @default.
- W2022609984 creator A5007121162 @default.
- W2022609984 creator A5038268084 @default.
- W2022609984 creator A5038844752 @default.
- W2022609984 creator A5039575338 @default.
- W2022609984 creator A5042069499 @default.
- W2022609984 creator A5062019346 @default.
- W2022609984 creator A5066334074 @default.
- W2022609984 creator A5082700940 @default.
- W2022609984 creator A5086501624 @default.
- W2022609984 date "1990-01-01" @default.
- W2022609984 modified "2023-10-11" @default.
- W2022609984 title "Regulation of Proliferation by Fibroblast Growth Factor in a Pancreatic Cancer Cell Line" @default.
- W2022609984 doi "https://doi.org/10.1159/000200380" @default.
- W2022609984 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2262049" @default.
- W2022609984 hasPublicationYear "1990" @default.
- W2022609984 type Work @default.
- W2022609984 sameAs 2022609984 @default.
- W2022609984 citedByCount "7" @default.
- W2022609984 countsByYear W20226099842019 @default.
- W2022609984 crossrefType "journal-article" @default.
- W2022609984 hasAuthorship W2022609984A5006481318 @default.
- W2022609984 hasAuthorship W2022609984A5007121162 @default.
- W2022609984 hasAuthorship W2022609984A5038268084 @default.
- W2022609984 hasAuthorship W2022609984A5038844752 @default.
- W2022609984 hasAuthorship W2022609984A5039575338 @default.
- W2022609984 hasAuthorship W2022609984A5042069499 @default.
- W2022609984 hasAuthorship W2022609984A5062019346 @default.
- W2022609984 hasAuthorship W2022609984A5066334074 @default.
- W2022609984 hasAuthorship W2022609984A5082700940 @default.
- W2022609984 hasAuthorship W2022609984A5086501624 @default.
- W2022609984 hasConcept C121289238 @default.
- W2022609984 hasConcept C126322002 @default.
- W2022609984 hasConcept C134018914 @default.
- W2022609984 hasConcept C170493617 @default.
- W2022609984 hasConcept C181199279 @default.
- W2022609984 hasConcept C24998067 @default.
- W2022609984 hasConcept C2775960820 @default.
- W2022609984 hasConcept C2777587049 @default.
- W2022609984 hasConcept C54355233 @default.
- W2022609984 hasConcept C55493867 @default.
- W2022609984 hasConcept C62112901 @default.
- W2022609984 hasConcept C71924100 @default.
- W2022609984 hasConcept C74373430 @default.
- W2022609984 hasConcept C79879829 @default.
- W2022609984 hasConcept C81885089 @default.
- W2022609984 hasConcept C86803240 @default.
- W2022609984 hasConcept C95444343 @default.
- W2022609984 hasConceptScore W2022609984C121289238 @default.
- W2022609984 hasConceptScore W2022609984C126322002 @default.
- W2022609984 hasConceptScore W2022609984C134018914 @default.
- W2022609984 hasConceptScore W2022609984C170493617 @default.
- W2022609984 hasConceptScore W2022609984C181199279 @default.
- W2022609984 hasConceptScore W2022609984C24998067 @default.
- W2022609984 hasConceptScore W2022609984C2775960820 @default.
- W2022609984 hasConceptScore W2022609984C2777587049 @default.
- W2022609984 hasConceptScore W2022609984C54355233 @default.
- W2022609984 hasConceptScore W2022609984C55493867 @default.
- W2022609984 hasConceptScore W2022609984C62112901 @default.
- W2022609984 hasConceptScore W2022609984C71924100 @default.
- W2022609984 hasConceptScore W2022609984C74373430 @default.
- W2022609984 hasConceptScore W2022609984C79879829 @default.
- W2022609984 hasConceptScore W2022609984C81885089 @default.
- W2022609984 hasConceptScore W2022609984C86803240 @default.
- W2022609984 hasConceptScore W2022609984C95444343 @default.
- W2022609984 hasIssue "2" @default.
- W2022609984 hasLocation W20226099841 @default.
- W2022609984 hasLocation W20226099842 @default.
- W2022609984 hasOpenAccess W2022609984 @default.
- W2022609984 hasPrimaryLocation W20226099841 @default.
- W2022609984 hasRelatedWork W1965601240 @default.
- W2022609984 hasRelatedWork W2014381685 @default.
- W2022609984 hasRelatedWork W2037740673 @default.
- W2022609984 hasRelatedWork W2059767485 @default.
- W2022609984 hasRelatedWork W2069681533 @default.
- W2022609984 hasRelatedWork W2074797560 @default.
- W2022609984 hasRelatedWork W2347430764 @default.
- W2022609984 hasRelatedWork W2364776610 @default.
- W2022609984 hasRelatedWork W3148797584 @default.
- W2022609984 hasRelatedWork W3151213009 @default.
- W2022609984 hasVolume "46" @default.
- W2022609984 isParatext "false" @default.
- W2022609984 isRetracted "false" @default.
- W2022609984 magId "2022609984" @default.
- W2022609984 workType "article" @default.