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- W2022631666 abstract "The ability of a number of anti-tumour agents to elevate the intracellular level of adenosine 3′,5′-monophosphate (cyclic AMP) in Walker carcinoma has been investigated. Of these agents HN2, chlorambucil, merophan, CB 1954, and cis-dichloro diammine Pt II [cis-Cl2(NH3)2 Pt II) caused appreciable elevations of the cyclic nucleotide. These compounds are all regarded as having a typical alkylating agent spectrum of action. A linear relationship was obtained between the intracellular cyclic AMP level produced by a given dose of cis-Cl2(NH3)2 Pt II and the observed percentage inhibition of cell growth. There was a rapid elevation of cyclic AMP in response to chlorambucil which reached its peak within 1 hr of treatment. This preceded the inhibition of thymidine incorporation which reached 50 per cent by 7 hr. 1,3-Bis(2-chloroethyl)1-nitrosourea (BCNU) and (±) 1,2-bis-(3,5-dioxopiperazin-1-yl)propane (ICRF 159) had no effect on the intracellular level of cyclic AMP in Walker carcinoma at any dose level studied. The cyclic 3′,5′-nucleotide phosphodiesterase from bone marrow and intestinal mucosa, two tissues susceptible to alkylating agents, has been investigated. This enzyme behaves kinetically as if two separate activities exist, one with a low affinity for the substrate and the other with a high affinity. The distribution of the two forms of the enzyme from these tissues agrees with the correlation previously obtained between sensitivity to alkylating agents and a high percentage of the low Km form of the enzyme." @default.
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- W2022631666 date "1975-07-01" @default.
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- W2022631666 title "Comparative effects of alkylating agents and other anti-tumour agents on the intracellular level of adenosine 3′,5′-monophosphate in Walker carcinoma" @default.
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- W2022631666 doi "https://doi.org/10.1016/0006-2952(75)90335-4" @default.
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