Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022631801> ?p ?o ?g. }
- W2022631801 endingPage "1965" @default.
- W2022631801 startingPage "1958" @default.
- W2022631801 abstract "We have studied biocompatible spherical carriers carrying a dodecapeptide, HHLGGAKQAGDV (H12), on their surface as platelet substitutes. This peptide is a fibrinogen γ-chain carboxy-terminal sequence (γ400-411) and specifically recognizes the active form of glycoprotein IIb/IIIa on activated platelets. Our purpose is to assess the possibility of making a novel platelet substitute consisting of disk-shaped nanosheets having a large contact area for the targeting site, rather than conventional small contact area spherical carriers. The H12 peptide was conjugated to the surface of the free-standing nanosheets made of biodegradable poly(d,l-lactide-co-glycolide) (PLGA). These H12-PLGA nanosheets were fabricated onto 3 μm disk-shaped patterned hydrophobic octadecyl regions on a SiO(2) substrate. By way of comparison, spherical H12-PLGA microparticles with the same surface area and conjugation number of H12 were also prepared. The resulting H12-PLGA nanosheets specifically interacted with the activated platelets adhered on the collagen surface at twice the rate of the H12-PLGA microparticles under flow conditions, and showed platelet thrombus formation in a two-dimensional spreading manner. Thus, H12-PLGA nanosheets might be a suitable candidate novel platelet alternative substitute for infused human platelet concentrates for the treatment of bleeding in patients with severe thrombocytopenia." @default.
- W2022631801 created "2016-06-24" @default.
- W2022631801 creator A5003711905 @default.
- W2022631801 creator A5037131620 @default.
- W2022631801 creator A5058909601 @default.
- W2022631801 creator A5063584467 @default.
- W2022631801 creator A5071699411 @default.
- W2022631801 creator A5074835045 @default.
- W2022631801 creator A5086525882 @default.
- W2022631801 date "2009-09-29" @default.
- W2022631801 modified "2023-10-16" @default.
- W2022631801 title "Novel Platelet Substitutes: Disk-Shaped Biodegradable Nanosheets and their Enhanced Effects on Platelet Aggregation" @default.
- W2022631801 cites W1505283703 @default.
- W2022631801 cites W1533499340 @default.
- W2022631801 cites W1586686759 @default.
- W2022631801 cites W1972845382 @default.
- W2022631801 cites W1976366973 @default.
- W2022631801 cites W1979790512 @default.
- W2022631801 cites W1980651080 @default.
- W2022631801 cites W1981131409 @default.
- W2022631801 cites W1982096781 @default.
- W2022631801 cites W1990755863 @default.
- W2022631801 cites W1994974902 @default.
- W2022631801 cites W1997435827 @default.
- W2022631801 cites W1998621525 @default.
- W2022631801 cites W2017522580 @default.
- W2022631801 cites W2018334262 @default.
- W2022631801 cites W2022948419 @default.
- W2022631801 cites W2025635935 @default.
- W2022631801 cites W2028254530 @default.
- W2022631801 cites W2042358686 @default.
- W2022631801 cites W2043570500 @default.
- W2022631801 cites W2045396240 @default.
- W2022631801 cites W2049863803 @default.
- W2022631801 cites W2051247565 @default.
- W2022631801 cites W2055870792 @default.
- W2022631801 cites W2058547982 @default.
- W2022631801 cites W2059180309 @default.
- W2022631801 cites W2066316096 @default.
- W2022631801 cites W2067836657 @default.
- W2022631801 cites W2068424904 @default.
- W2022631801 cites W2073095639 @default.
- W2022631801 cites W2085508149 @default.
- W2022631801 cites W2090406006 @default.
- W2022631801 cites W2098438673 @default.
- W2022631801 cites W2114286636 @default.
- W2022631801 cites W2127336590 @default.
- W2022631801 cites W2128163302 @default.
- W2022631801 cites W2156368993 @default.
- W2022631801 cites W4211141663 @default.
- W2022631801 cites W4323284762 @default.
- W2022631801 doi "https://doi.org/10.1021/bc900325w" @default.
- W2022631801 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19788180" @default.
- W2022631801 hasPublicationYear "2009" @default.
- W2022631801 type Work @default.
- W2022631801 sameAs 2022631801 @default.
- W2022631801 citedByCount "35" @default.
- W2022631801 countsByYear W20226318012012 @default.
- W2022631801 countsByYear W20226318012013 @default.
- W2022631801 countsByYear W20226318012014 @default.
- W2022631801 countsByYear W20226318012015 @default.
- W2022631801 countsByYear W20226318012016 @default.
- W2022631801 countsByYear W20226318012017 @default.
- W2022631801 countsByYear W20226318012019 @default.
- W2022631801 countsByYear W20226318012020 @default.
- W2022631801 countsByYear W20226318012021 @default.
- W2022631801 countsByYear W20226318012022 @default.
- W2022631801 crossrefType "journal-article" @default.
- W2022631801 hasAuthorship W2022631801A5003711905 @default.
- W2022631801 hasAuthorship W2022631801A5037131620 @default.
- W2022631801 hasAuthorship W2022631801A5058909601 @default.
- W2022631801 hasAuthorship W2022631801A5063584467 @default.
- W2022631801 hasAuthorship W2022631801A5071699411 @default.
- W2022631801 hasAuthorship W2022631801A5074835045 @default.
- W2022631801 hasAuthorship W2022631801A5086525882 @default.
- W2022631801 hasConcept C111368507 @default.
- W2022631801 hasConcept C112613896 @default.
- W2022631801 hasConcept C12554922 @default.
- W2022631801 hasConcept C127313418 @default.
- W2022631801 hasConcept C127413603 @default.
- W2022631801 hasConcept C171250308 @default.
- W2022631801 hasConcept C178790620 @default.
- W2022631801 hasConcept C185592680 @default.
- W2022631801 hasConcept C188027245 @default.
- W2022631801 hasConcept C192562407 @default.
- W2022631801 hasConcept C202751555 @default.
- W2022631801 hasConcept C203014093 @default.
- W2022631801 hasConcept C2777289219 @default.
- W2022631801 hasConcept C2779036427 @default.
- W2022631801 hasConcept C2780165375 @default.
- W2022631801 hasConcept C42360764 @default.
- W2022631801 hasConcept C521977710 @default.
- W2022631801 hasConcept C55493867 @default.
- W2022631801 hasConcept C86803240 @default.
- W2022631801 hasConcept C89560881 @default.
- W2022631801 hasConceptScore W2022631801C111368507 @default.
- W2022631801 hasConceptScore W2022631801C112613896 @default.
- W2022631801 hasConceptScore W2022631801C12554922 @default.