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- W2022632835 abstract "The old adage that it is easier to avoid a problem than to fix it is a good principle, but not always practicable in real life. In sickle-cell disease, diagnosis via haemoglobinopathy screening in newborn babies allows implementation of treatment that includes early initiation of penicillin prophylaxis and immunisations against encapsulated bacterial pathogens, which together reduce morbidity and mortality in the first 5 years of life. 1 Gaston MH Verter JI Woods G et al. Prophylaxis with oral penicillin in children with sickle cell anemia: a randomized trial. N Engl J Med. 1986; 314: 1593-1599 Crossref PubMed Scopus (915) Google Scholar , 2 Adamkiewicz TV Silk BJ Howgate J et al. Effectiveness of the 7-valent pneumococcal conjugate vaccine in children with sickle cell disease in the first decade of life. Pediatrics. 2008; 121: 562-569 Crossref PubMed Scopus (123) Google Scholar , 3 Vichinsky E Hurst D Earles A Kleman K Lubin B Newborn screening for sickle cell disease: effect on mortality. Pediatrics. 1988; 81: 749-755 PubMed Google Scholar However, doubts about effectiveness continue to be raised, precisely in areas of the world where the disease is most common. Institution of universal haemoglobinopathy screening in Africa is understandably hampered by costs and organisational challenges, but also has been fettered by questions about supposed differences in the types and susceptibility of pathogens between the northern and southern hemispheres, the former being where most scientific evidence to support prophylactic measures derives. Bacteraemia in Kenyan children with sickle-cell anaemia: a retrospective cohort and case–control studyThe organisms causing bacteraemia in African children with sickle-cell anaemia are the same as those in developed countries. Introduction of conjugate vaccines against S pneumoniae and H influenzae into the childhood immunisation schedules of African countries could substantially affect survival of children with sickle-cell anaemia. Full-Text PDF Open Access" @default.
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- W2022632835 date "2009-10-01" @default.
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- W2022632835 title "Sickle-cell disease: an ounce of prevention, a pound of cure" @default.
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- W2022632835 doi "https://doi.org/10.1016/s0140-6736(09)61602-0" @default.
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