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• W2022634418 abstract "The chronic inhibition of nitric oxide (NO) synthesis with N(omega)-Nitro-L-arginine methyl ester (L-NAME) induces a pre-eclampsia-like syndrome including hypertension in pregnant rats. We tested the traditional herbal medicines Saireito (SR) and Boiogito (BO), which have been used clinically for the treatment of pre-eclampsia, in this model. L-NAME was infused subcutaneously into pregnant rats from gestational day 14 (G14). SR and BO (both at 1, 2g/kg) were administered by gavage from G14 to G20. Systolic blood pressure was measured on G19. SR and BO (both at 1, 2g/kg) inhibited L-NAME-induced hypertension. SR was effective in both pregnant and non-pregnant rats while BO was effective only in pregnant rats. BO increased blood levels of CGRP and decreased levels of endothelin-1; both are known to play important roles in regulation of blood pressure in pre-eclampsia. SR and BO may be beneficial for the treatment and prevention of hypertension in pre-eclampsia." @default.
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• W2022634418 date "2007-09-01" @default.
• W2022634418 modified "2023-10-16" @default.
• W2022634418 title "The herbal medicines Saireito and Boiogito improve the hypertension of pre-eclamptic rats induced by Nω-Nitro-l-arginine methyl ester" @default.
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• W2022634418 doi "https://doi.org/10.1016/j.phymed.2007.01.009" @default.
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