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- W2022635031 abstract "Objectives– Paraoxonase, angiotensin-converting enzyme (ACE), methylenetetrahydrofolate reductase (MTHFR), and apo E gene polymorphisms were evaluated in older patients with vascular dementia (VD) or late-onset Alzheimer's disease (LOAD). Material and methods– Sixty patients with VD, 45 patients with LOAD, and 54 non-demented controls were compared. Results– No differences in the distribution of paraoxonase, ACE, and MTHFR polymorphisms were found. The overall frequency of apo E ε4 allele was “low”; ε4 allele was more frequent in LOAD (17.5%) and VD (13.3%) compared with controls (9.2%), but the difference was not statistically significant. Conclusion– Paraoxonase, ACE, and MTHFR polymorphisms were not associated with VD or LOAD; these common polymorphisms might have a marginal role in the pathogenesis of dementia in older subjects. In spite of a “low” frequency of the apo E ε4 allele in our sample, the frequency of ε4 allele was about double in LOAD compared with controls." @default.
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- W2022635031 date "2001-05-01" @default.
- W2022635031 modified "2023-10-18" @default.
- W2022635031 title "Genetic polymorphisms in older subjects with vascular or Alzheimer's dementia" @default.
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- W2022635031 doi "https://doi.org/10.1034/j.1600-0404.2001.103005304.x" @default.
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