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• W2022638065 abstract "Abstract The rate of protein synthesis by human granulocytes in vitro has been measured by the incorporation of [U- 14 C]phenylalanine into the cell protein. The total phenylalanine concentration in the cells was measured in each experiment so that changes in the precursor pool specific radioactivity during the experiment could be allowed for. Cells were obtained from normal subjects, patients who had recovered from an episode of idiosyncratic drug-induced neutropenia, and from a case of idiopathic neutropenia. The effects of the following drugs which sometimes cause idiosyncratic neutropenia, on the rate of protein synthesis in human granulocytes in vitro has been studied: sodium aurothiomalate, phenylbutazone, carbimazole, methimazole, methylthiouracil, chlorpromazine, chloramphenicol, sulphamethoxazole and trimethoprim. The last two drugs were studied separately, and in combination in the proportions in which they are found in plasma during co-trimoxazole therapy. When used at the concentrations which are believed to represent the maximum in vivo concentrations in serum, none of the following affected the protein synthetic activity of normal human granulocytes in vitro : sodium aurothiomalate, phenylbutazone, methimazole, methylthiouracil, sulphamethoxazole and trimethoprim (the latter pair either separately or together as in co-trimoxazole). Chlorpromazine (1 × 10 −4 M) markedly inhibited protein synthesis by the cells of one normal subject out of the 10 who were studied. Higher concentrations (1 × 10 −3 M) of chlorpromazine virtually abolished protein synthesis in the cells of the two normal subjects studied. Chloramphenicol reduced the protein synthetic activity of normal human granulocytes. We obtained no evidence that protein synthesis by the granulocytes from patients who had experienced neutropenia due to sodium aurothiomalate (4 cases), chloramphenicol (2 cases), carbimazole (1 case), co-trimoxazole (1 case), methylthiouracil (1 case) were abnormally sensitive to inhibition by the drug which had caused the neutropenia." @default.
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• W2022638065 title "The effects of some drugs which cause agranulocytosis on protein synthesis in human granulocytes" @default.
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• W2022638065 doi "https://doi.org/10.1016/0006-2952(75)90149-5" @default.
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