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• W2022641600 abstract "Thrombolytic therapy is available worldwide for the treatment for acute myocardial infarction, and streptokinase is frequently used. Although early reperfusion salvages myocardium, 1 Simes R.J. Topol E.J. Holmes Jr, D.R. White H.D. Wolfgang R.R. Vahanian A. Simoons M.L. Morris D. Betriu A. Califf R.M. Ross A.M. Link between the angiographic substudy and mortality outcomes in a large randomized trial of myocardial reperfusion. GUSTO-1 investigators. Circulation. 1995; 91: 1923-1928 Crossref PubMed Scopus (464) Google Scholar , 2 GUSTO Angiographic InvestigatorsThe effects of tissue plasminogen activator, streptokinase or both on coronary artery patency, ventricular function and survival after acute myocardial infarction. N Engl J Med. 1993; 329: 1615-1622 Crossref PubMed Scopus (1884) Google Scholar reperfusion after 90 minutes is also beneficial through preventing ventricular dilatation, improving electrical stability, and providing collateral flow when another artery occludes. 3 White H.D. Should all occluded infarct-related arteries be opened?. Eur Heart J. 1997; 18 ([editorial]): 1207-1209 Crossref PubMed Scopus (20) Google Scholar However, reocclusion of the infarct-related artery after initial recanalization sometimes occurs and increases mortality. 4 Ohman E.M. Carliff R.M. Topol E.J. Candela R. Abbotsmith C. Ellis S. Sigmon K.N. Kereiakes D. George B. Stack R. TAMI Study GroupConsequences of reocclusion after successful reperfusion therapy in acute myocardial infarction. Circulation. 1990; 82: 781-791 Crossref PubMed Scopus (428) Google Scholar In the Hirulog Early Reperfusion/Occlusion (HERO-1) trial, there was a lower rate of Thrombolysis In Myocardial Infarction trial (TIMI) grade 3 flow at 90 minutes in patients who received streptokinase >3 hours after symptom onset, 5 White H.D. Aylward P.E. Frey M.J. Adgey A.A. Nair R. Hillis W.S. Shalev Y. Brown M.A. French J.K. Collins R. Maraganore J. Adelman B. Hirulog Early Reperfusion/Occlusion (HERO) Trial InvestigatorsA randomized, double blind comparison of hirulog versus heparin in patients receiving streptokinase and aspirin for acute myocardial infarction. Circulation. 1997; 96 (HERO): 2155-2161 Crossref PubMed Scopus (241) Google Scholar , 6 Wong C.K. French J.K. Alyward P.E. Frey M.J. Adgey A.A.J. White H.D. Usefulness of presenting electrocardiogram in predicting successful reperfusion with streptokinase in acute myocardial infarction. Am J Cardiol. 1999; 83: 164-168 Abstract Full Text Full Text PDF PubMed Scopus (39) Google Scholar and in patients with pathologic Q waves at presentation. 6 Wong C.K. French J.K. Alyward P.E. Frey M.J. Adgey A.A.J. White H.D. Usefulness of presenting electrocardiogram in predicting successful reperfusion with streptokinase in acute myocardial infarction. Am J Cardiol. 1999; 83: 164-168 Abstract Full Text Full Text PDF PubMed Scopus (39) Google Scholar Whether these “late presenting” patients have more recanalization or fare worse from reocclusion of the infarct-related artery after the first 90 minutes is unknown. In this study, we analyze the relations between early changes of infarct-related artery flow, time to treatment, and Q waves at presentation." @default.
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• W2022641600 title "Relation of pathologic Q waves at presentation and time to streptokinase therapy with early changes in infarct-related artery flow and ventricular wall motion" @default.
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