FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022642255> ?p ?o ?g. }

• W2022642255 endingPage "193" @default.
• W2022642255 startingPage "185" @default.
• W2022642255 abstract "The thyrotropin (TSH) level or duration of thyroid hormone withdrawal (THW) required to detect stimulated thyroglobulin (Tg) in differentiated thyroid cancer (DTC) monitoring is unknown. The objective of this study was to evaluate the TSH cutoff of >30 μU/mL as a means to detect stimulated Tg ≥2 ng/mL after THW (THW-Tg≥2), and sensitivity of the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) questionnaire for detecting hypothyroid symptoms.This was a prospective longitudinal cohort study done at a tertiary academic medical center. Forty-seven patients with DTC undergoing their first Tg stimulation or after previously abnormal Tg stimulation had weekly measurements of TSH and Tg during the 4 weeks THW, and repeated questionnaire assessments.TSH did not reach a plateau in any patient, and in those whose Tg did not remain undetectable, Tg continued to rise. Seventy-five percent of patients had an undetectable Tg <0.2 ng/mL at baseline (95% were <0.5 mg/mL) with 16% remaining undetectable throughout THW. The majority of patients (72.7% and 97.8%) achieved TSH >30 μU/mL by 3 and 4 weeks THW, respectively. Of the 15 patients with maximum stimulated THW-Tg≥2, 38% were detected before the minimal TSH >30 μU/mL cutoff. At 2 weeks THW, 3 had a TSH>30 μU/mL, and none of them had Tg ≥2 ng/mL. At 3 weeks THW, 11 had a TSH >30 μU/mL, and 64% of them had Tg ≥2 ng/mL. Only 60% were detected at 3-week THW regardless of their TSH level. Eighty-six percent were detected by TSH 60-<80 μU/mL. Conversely, all patients whose serum Tg was <0.2 ng/mL when their serum TSH was >20 μU/mL did not achieve a THW-Tg≥2.The minimal TSH cutoff of >30 μU/mL was inadequate to detect many patients with final stimulated THW-Tg≥2 during complete THW. TSH >80-100 μU/mL was a better cutoff, achieved in only 53% after 4-week THW. Conversely, we propose a preliminary THW-stopping rule for ending THW early in selected patients. In patients with a Tg <0.2 ng/mL when TSH >20 μU/mL, all had a final stimulated Tg ≤2 ng/mL, potentially saving qualifying patients 40% of THW duration compared to 4-week THW. FACIT-F correlated with TSH, but was not sensitive to detect mild hypothyroidism." @default.
• W2022642255 created "2016-06-24" @default.
• W2022642255 creator A5012516957 @default.
• W2022642255 creator A5025094934 @default.
• W2022642255 creator A5048390221 @default.
• W2022642255 creator A5055111692 @default.
• W2022642255 creator A5070614030 @default.
• W2022642255 creator A5080455457 @default.
• W2022642255 creator A5087489933 @default.
• W2022642255 date "2013-02-01" @default.
• W2022642255 modified "2023-09-26" @default.
• W2022642255 title "In Thyroidectomized Patients with Thyroid Cancer, a Serum Thyrotropin of 30 <i>μ</i>U/mL After Thyroxine Withdrawal Is Not Always Adequate for Detecting an Elevated Stimulated Serum Thyroglobulin" @default.
• W2022642255 cites W1922875389 @default.
• W2022642255 cites W1970686795 @default.
• W2022642255 cites W1976845830 @default.
• W2022642255 cites W1978632252 @default.
• W2022642255 cites W1993041398 @default.
• W2022642255 cites W1999980131 @default.
• W2022642255 cites W2013548700 @default.
• W2022642255 cites W2024550057 @default.
• W2022642255 cites W2026228520 @default.
• W2022642255 cites W2029872319 @default.
• W2022642255 cites W2035679318 @default.
• W2022642255 cites W2041543569 @default.
• W2022642255 cites W2042031487 @default.
• W2022642255 cites W2067449061 @default.
• W2022642255 cites W2075209973 @default.
• W2022642255 cites W2078570055 @default.
• W2022642255 cites W2081487777 @default.
• W2022642255 cites W2087514465 @default.
• W2022642255 cites W2095260570 @default.
• W2022642255 cites W2102022889 @default.
• W2022642255 cites W2102269942 @default.
• W2022642255 cites W2105331274 @default.
• W2022642255 cites W2106878488 @default.
• W2022642255 cites W2108800970 @default.
• W2022642255 cites W2116542352 @default.
• W2022642255 cites W2140936682 @default.
• W2022642255 cites W2142478663 @default.
• W2022642255 cites W2144894830 @default.
• W2022642255 cites W2145982910 @default.
• W2022642255 cites W2148041139 @default.
• W2022642255 cites W2151884471 @default.
• W2022642255 cites W2164240074 @default.
• W2022642255 cites W4229514619 @default.
• W2022642255 cites W4233587887 @default.
• W2022642255 cites W4245394820 @default.
• W2022642255 doi "https://doi.org/10.1089/thy.2012.0327" @default.
• W2022642255 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3919477" @default.
• W2022642255 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22978687" @default.
• W2022642255 hasPublicationYear "2013" @default.
• W2022642255 type Work @default.
• W2022642255 sameAs 2022642255 @default.
• W2022642255 citedByCount "24" @default.
• W2022642255 countsByYear W20226422552013 @default.
• W2022642255 countsByYear W20226422552014 @default.
• W2022642255 countsByYear W20226422552015 @default.
• W2022642255 countsByYear W20226422552016 @default.
• W2022642255 countsByYear W20226422552017 @default.
• W2022642255 countsByYear W20226422552018 @default.
• W2022642255 countsByYear W20226422552020 @default.
• W2022642255 countsByYear W20226422552021 @default.
• W2022642255 countsByYear W20226422552022 @default.
• W2022642255 crossrefType "journal-article" @default.
• W2022642255 hasAuthorship W2022642255A5012516957 @default.
• W2022642255 hasAuthorship W2022642255A5025094934 @default.
• W2022642255 hasAuthorship W2022642255A5048390221 @default.
• W2022642255 hasAuthorship W2022642255A5055111692 @default.
• W2022642255 hasAuthorship W2022642255A5070614030 @default.
• W2022642255 hasAuthorship W2022642255A5080455457 @default.
• W2022642255 hasAuthorship W2022642255A5087489933 @default.
• W2022642255 hasBestOaLocation W20226422552 @default.
• W2022642255 hasConcept C126322002 @default.
• W2022642255 hasConcept C134018914 @default.
• W2022642255 hasConcept C2777886399 @default.
• W2022642255 hasConcept C2778835679 @default.
• W2022642255 hasConcept C2779761222 @default.
• W2022642255 hasConcept C526584372 @default.
• W2022642255 hasConcept C71924100 @default.
• W2022642255 hasConcept C90924648 @default.
• W2022642255 hasConceptScore W2022642255C126322002 @default.
• W2022642255 hasConceptScore W2022642255C134018914 @default.
• W2022642255 hasConceptScore W2022642255C2777886399 @default.
• W2022642255 hasConceptScore W2022642255C2778835679 @default.
• W2022642255 hasConceptScore W2022642255C2779761222 @default.
• W2022642255 hasConceptScore W2022642255C526584372 @default.
• W2022642255 hasConceptScore W2022642255C71924100 @default.
• W2022642255 hasConceptScore W2022642255C90924648 @default.
• W2022642255 hasIssue "2" @default.
• W2022642255 hasLocation W20226422551 @default.
• W2022642255 hasLocation W20226422552 @default.
• W2022642255 hasLocation W20226422553 @default.
• W2022642255 hasLocation W20226422554 @default.
• W2022642255 hasOpenAccess W2022642255 @default.
• W2022642255 hasPrimaryLocation W20226422551 @default.
• W2022642255 hasRelatedWork W1972113515 @default.
• W2022642255 hasRelatedWork W1981968121 @default.
• W2022642255 hasRelatedWork W1994866942 @default.

• next