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- W2022643007 abstract "Abstract Transformed fibroblasts are agglutinated by concanavalin A (ConA) at concentrations that do not agglutinate normal fibroblasts. Preincubation with the divalent cation ionophore A23187 and calcium resulted in a loss of ConA agglutinability in the transformed fibroblasts and a gain of agglutinability in the normal fibroblasts. These changes were not obtained in the absence of added calcium or in the presence of manganese or magnesium and were associated with an ionophore induced calcium influx. Cap formation by ConA on myeloid leukemic cells was inhibited by the ionophore in the absence of added calcium. This inhibition of cap formation was associated with calcium outflux and was reversed by the addition of manganese or magnesium. The normal and transformed fibroblasts had a similar amount of surface microvilli. Incubation with the ionophore A23187 inhibited the formation of microvilli on transformed but not on normal fibroblasts and this inhibition occurred only in the presence of added calcium. Surface microvilli on transformed fibroblasts were also more sensitive to inhibition by cytochalasin B (CB), but there was no effect of CB on the ConA agglutinability of the treated cells. In both types of fibroblasts, microvilli formation was stimulated by ATP depletion and inhibited by incubation with local anesthetics, ConA, wheat germ agglutinin (WGA), or wax bean agglutinin (WBA). It is suggested that calcium dependent changes in cytoplasmic microtubules and microfilaments can induce changes in cell agglutinability and surface microvilli and that differences in the calcium regulation of these properties in normal and transformed fibroblasts are due to differences in the organization of cytoskeletal components and their association with the surface membrane." @default.
- W2022643007 created "2016-06-24" @default.
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- W2022643007 date "1977-03-01" @default.
- W2022643007 modified "2023-09-25" @default.
- W2022643007 title "Difference in the calcium regulation of concanavalin A agglutinability and surface microvilli in normal and transformed cells Relationship to membrane-cytoskeleton interaction" @default.
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- W2022643007 doi "https://doi.org/10.1016/0014-4827(77)90164-1" @default.
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