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• W2022643724 abstract "Actin filaments, microtubules, and intermediate filaments (IFs) are central elements of the metazoan cytoskeleton. At the molecular level, the assembly mechanism for actin filaments and microtubules is fundamentally different from that of IFs. The former two types of filaments assemble from globular proteins. By contrast, IFs assemble from tetrameric complexes of extended, half-staggered, and antiparallel oriented coiled-coils. These tetramers laterally associate into unit-length filaments; subsequent longitudinal annealing of unit-length filaments yields mature IFs. In vitro, IFs form open structures without a fixed number of tetramers per cross-section along the filament. Therefore, a central question for the structural biology of IFs is whether individual subunits can dissociate from assembled filaments and rebind at other sites. Using the fluorescently labeled IF-protein vimentin for assembly, we directly observe and quantitatively determine subunit exchange events between filaments as well as with soluble vimentin pools. Thereby we demonstrate that the cross-sectional polymorphism of donor and acceptor filaments plays an important role. We propose that in segments of donor filaments with more than the standard 32 molecules per cross-section, subunits are not as tightly bound and are predisposed to be released from the filament." @default.
• W2022643724 created "2016-06-24" @default.
• W2022643724 creator A5052025914 @default.
• W2022643724 creator A5057266174 @default.
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• W2022643724 date "2014-12-01" @default.
• W2022643724 modified "2023-10-02" @default.
• W2022643724 title "Direct Observation of Subunit Exchange along Mature Vimentin Intermediate Filaments" @default.
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• W2022643724 doi "https://doi.org/10.1016/j.bpj.2014.09.050" @default.
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