FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022644112> ?p ?o ?g. }

• W2022644112 endingPage "5601" @default.
• W2022644112 startingPage "5594" @default.
• W2022644112 abstract "The systemic toxicity of three candidate HIV-1 vaccines plasmid pSG2.HIVconsv DNA (D), ChAdV63.HIVconsv (C) and MVA.HIVconsv (M) expressing chimeric immunogen derived from the most conserved regions of the HIV-1 proteome was evaluated in two repeat-dose studies in the male and female BALB/c mice.In study UNO011, mice received three doses of 2×10(7) plaque-forming units of MVA.HIVconsv vaccine (MMM). In study UNO012, mice received 3 doses of 50μg of pSG2.HIVconsv DNA followed by a single dose of 5.95×10(9) virus particles of ChAdV63.HIVconsv vaccine (DDDC). Similarly constituted control groups received the vehicle alone (phosphate buffered saline) at the same volume-dose. All vaccines were administered by intramuscular needle injection into the right hind limb at 14-day intervals and animals were sacrificed 7 days after the last dose. Assessment of local and systemic toxicity was made. Induction of HIV-1-specific responses was confirmed. Parameters assessed included clinical condition, body weight, food consumption, ophthalmoscopy, haematology, blood chemistry, organ weight and macroscopic and microscopic pathology.In both studies, treatment with the candidate vaccines elicited strong HIV-1-specific T-cell responses. The vaccine treatment was well-tolerated without any adverse systemic toxicological changes. The local toxicity findings observed in these studies were consistent with the predicted response to a vaccine/substance administration by intramuscular injection.The three novel anti-HIV-1 vaccines were well tolerated when administered by intramuscular injection to BALB/c mice. These results supported an application for authorisation by the Medicines and Healthcare Products Regulatory Agency of the UK to test these vaccines for the first time in phase I clinical trials in healthy both uninfected subjects and HIV-1-infected patients stable on antiretroviral treatment." @default.
• W2022644112 created "2016-06-24" @default.
• W2022644112 creator A5008680262 @default.
• W2022644112 creator A5014239001 @default.
• W2022644112 creator A5022640226 @default.
• W2022644112 creator A5032098241 @default.
• W2022644112 creator A5060053954 @default.
• W2022644112 date "2013-11-01" @default.
• W2022644112 modified "2023-10-16" @default.
• W2022644112 title "Absence of systemic toxicity changes following intramuscular administration of novel pSG2.HIVconsv DNA, ChAdV63.HIVconsv and MVA.HIVconsv vaccines to BALB/c mice" @default.
• W2022644112 cites W1983792088 @default.
• W2022644112 cites W1987810275 @default.
• W2022644112 cites W2019735973 @default.
• W2022644112 cites W2030388818 @default.
• W2022644112 cites W2041434802 @default.
• W2022644112 cites W2044812530 @default.
• W2022644112 cites W2055418071 @default.
• W2022644112 cites W2058126118 @default.
• W2022644112 cites W2105595963 @default.
• W2022644112 cites W2112939215 @default.
• W2022644112 cites W2143421242 @default.
• W2022644112 cites W2321470707 @default.
• W2022644112 doi "https://doi.org/10.1016/j.vaccine.2013.06.068" @default.
• W2022644112 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3898262" @default.
• W2022644112 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23831324" @default.
• W2022644112 hasPublicationYear "2013" @default.
• W2022644112 type Work @default.
• W2022644112 sameAs 2022644112 @default.
• W2022644112 citedByCount "11" @default.
• W2022644112 countsByYear W20226441122014 @default.
• W2022644112 countsByYear W20226441122015 @default.
• W2022644112 countsByYear W20226441122018 @default.
• W2022644112 countsByYear W20226441122019 @default.
• W2022644112 countsByYear W20226441122021 @default.
• W2022644112 crossrefType "journal-article" @default.
• W2022644112 hasAuthorship W2022644112A5008680262 @default.
• W2022644112 hasAuthorship W2022644112A5014239001 @default.
• W2022644112 hasAuthorship W2022644112A5022640226 @default.
• W2022644112 hasAuthorship W2022644112A5032098241 @default.
• W2022644112 hasAuthorship W2022644112A5060053954 @default.
• W2022644112 hasBestOaLocation W20226441121 @default.
• W2022644112 hasConcept C126322002 @default.
• W2022644112 hasConcept C150903083 @default.
• W2022644112 hasConcept C159047783 @default.
• W2022644112 hasConcept C159654299 @default.
• W2022644112 hasConcept C167508917 @default.
• W2022644112 hasConcept C197934379 @default.
• W2022644112 hasConcept C203014093 @default.
• W2022644112 hasConcept C207001950 @default.
• W2022644112 hasConcept C25938499 @default.
• W2022644112 hasConcept C2776291583 @default.
• W2022644112 hasConcept C2777863537 @default.
• W2022644112 hasConcept C2779909307 @default.
• W2022644112 hasConcept C2780801004 @default.
• W2022644112 hasConcept C29730261 @default.
• W2022644112 hasConcept C542903549 @default.
• W2022644112 hasConcept C71924100 @default.
• W2022644112 hasConcept C86803240 @default.
• W2022644112 hasConcept C8891405 @default.
• W2022644112 hasConcept C98274493 @default.
• W2022644112 hasConceptScore W2022644112C126322002 @default.
• W2022644112 hasConceptScore W2022644112C150903083 @default.
• W2022644112 hasConceptScore W2022644112C159047783 @default.
• W2022644112 hasConceptScore W2022644112C159654299 @default.
• W2022644112 hasConceptScore W2022644112C167508917 @default.
• W2022644112 hasConceptScore W2022644112C197934379 @default.
• W2022644112 hasConceptScore W2022644112C203014093 @default.
• W2022644112 hasConceptScore W2022644112C207001950 @default.
• W2022644112 hasConceptScore W2022644112C25938499 @default.
• W2022644112 hasConceptScore W2022644112C2776291583 @default.
• W2022644112 hasConceptScore W2022644112C2777863537 @default.
• W2022644112 hasConceptScore W2022644112C2779909307 @default.
• W2022644112 hasConceptScore W2022644112C2780801004 @default.
• W2022644112 hasConceptScore W2022644112C29730261 @default.
• W2022644112 hasConceptScore W2022644112C542903549 @default.
• W2022644112 hasConceptScore W2022644112C71924100 @default.
• W2022644112 hasConceptScore W2022644112C86803240 @default.
• W2022644112 hasConceptScore W2022644112C8891405 @default.
• W2022644112 hasConceptScore W2022644112C98274493 @default.
• W2022644112 hasFunder F4320334626 @default.
• W2022644112 hasIssue "47" @default.
• W2022644112 hasLocation W20226441121 @default.
• W2022644112 hasLocation W20226441122 @default.
• W2022644112 hasLocation W20226441123 @default.
• W2022644112 hasLocation W20226441124 @default.
• W2022644112 hasOpenAccess W2022644112 @default.
• W2022644112 hasPrimaryLocation W20226441121 @default.
• W2022644112 hasRelatedWork W1594151399 @default.
• W2022644112 hasRelatedWork W2014500693 @default.
• W2022644112 hasRelatedWork W2056748701 @default.
• W2022644112 hasRelatedWork W2090324576 @default.
• W2022644112 hasRelatedWork W2162650424 @default.
• W2022644112 hasRelatedWork W2382653562 @default.
• W2022644112 hasRelatedWork W2392072650 @default.
• W2022644112 hasRelatedWork W2392175816 @default.
• W2022644112 hasRelatedWork W2594077466 @default.
• W2022644112 hasRelatedWork W3134379867 @default.
• W2022644112 hasVolume "31" @default.

• next