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- W2022644709 abstract "Significant morbidity and mortality result from bacterial infections in pediatric cardiac transplant (HTx) patients. Streptococcus pneumoniae (S pn) is the most common bacterial pathogen in childhood. Methods: We sought to better define the role of S pn as a cause of invasive disease in HTx patients. The HTx database and records of all HTx patients at our facility were reviewed to examine Spn infections post transplant. Demographic and clinical data were reviewed as well including outcome and morbidity. Results: 80 patients were studied; 76 patients had HTx at our institution. 42 patients were male. 60 patients were Caucasian (C), 18 were African-American (AA), and 2 were of other races. 53% percent of patients were diagnosed with congenital heart disease prior to transplant (CHD). 9 (11%) patients had 12 episodes of Spn bacteremia; 3 suffered 2 episodes. 2/3 of these patients were AA and the rest were C. Six underwent HTx for cardiomyopathy and 3 for CCHD. None had known asplenia. Affected patients had an average age of 9 months (2 wks - 2 yrs) at HTx. Spn infections occurred 3 to 48 mons after HTx (mean: 22 mons, median: 20 mons, S.D.: +/- 12.5 mons). Patients that were AA and those transplanted before 2 yrs of age were more likely to develop invasive infections (p<0.003). In only 3/12 episodes the patient was taking. Serogroup data included groups 19F, 14, 12, and 6A. Only 2 patients recieved the polysaccharide pneumococcal vaccine prior to their first. No deaths resulted from these episodes. Inferences: 11% of HTx patients had Spn bacteremia which is much higher than the incidence in the general population. Although most serious infections in HTx patients occur early after transplant, the Spn infections tend to occur later. Spn bacteremia is more common in AA patients and those transplanted at < 2 yrs of age, the age at which immunity to Spn normally develops. The use of the pneumococcal vaccines may be indicated post HTx in all patients but effectiveness remains to be determined." @default.
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- W2022644709 date "2001-02-01" @default.
- W2022644709 modified "2023-09-27" @default.
- W2022644709 title "Invasive pneumoccoccal infection in pediatric heart transplant patients" @default.
- W2022644709 doi "https://doi.org/10.1016/s1053-2498(00)00516-7" @default.
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