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- W2022647222 abstract "Multi-isotope imaging mass spectrometry (MIMS) is the quantitative imaging of stable isotope labels in cells with a new type of secondary ion mass spectrometer (NanoSIMS). The power of the methodology is attributable to (i) the immense advantage of using non-toxic stable isotope labels, (ii) high resolution imaging that approaches the resolution of usual transmission electron microscopy and (iii) the precise quantification of label down to 1 part-per-million and spanning several orders of magnitude. Here we review the basic elements of MIMS and describe new applications of MIMS to the quantitative study of metabolic processes including protein and nucleic acid synthesis in model organisms ranging from microbes to humans." @default.
- W2022647222 created "2016-06-24" @default.
- W2022647222 creator A5042528929 @default.
- W2022647222 creator A5065281981 @default.
- W2022647222 date "2013-08-01" @default.
- W2022647222 modified "2023-09-27" @default.
- W2022647222 title "Quantitative imaging of subcellular metabolism with stable isotopes and multi-isotope imaging mass spectrometry" @default.
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- W2022647222 doi "https://doi.org/10.1016/j.semcdb.2013.05.001" @default.
- W2022647222 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3985169" @default.
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