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• W2022647572 abstract "Interleukin-18 (IL-18) plays an important role in innate and acquired immunity. IL-18 gene deficient (IL-18-/-) mice of the 129×CD1 strain were reported to be more susceptible to Leishmania major infection than the wild-type mice. In contrast IL-18-/- mice of the C57BL/6 background were found to be as resistant as the wild-type (WT) mice. To resolve this discrepancy, IL-18 gene deficiency was introduced by backcrossing on to the highly susceptible BALB/c, or the moderately resistant DBA/1 backgrounds. Here we have demonstrated that BALB/c IL-18-/- mice were more resistant to L. major infection than WT BALB/c mice, whereas DBA/1 IL-18-/- mice were markedly more susceptible than their WT littermates. BALB/c IL-18-/- mice produced less IFNγ and IL-4, whereas DBA/1 IL-18ko mice produced more IFNγ and IL-4 than their respective WT controls. These result clearly demonstrate that the role of IL-18 in resistance or susceptibility to L. major is determined by host genetic background." @default.
• W2022647572 created "2016-06-24" @default.
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• W2022647572 date "2004-06-01" @default.
• W2022647572 modified "2023-10-14" @default.
• W2022647572 title "Host genetic background determines whether IL-18 deficiency results in increased susceptibility or resistance to murine Leishmania major infection" @default.
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• W2022647572 doi "https://doi.org/10.1016/j.imlet.2004.04.001" @default.
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